Age-sensitive T cell phenotypes covary in genetically heterogeneous mice and predict early death from lymphoma
| Autor: | Joyce E. Peterson, Jennifer Ruger, Gayle Gorgas, Simi Vancise, Richard A. Miller, Clarence E. Chrisp, Paul W. Turke, Kathy Chalmers, Ann Luciano |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Aging Lymphoma T cell Lymphocyte Population Longevity Receptors Lymphocyte Homing Mice Inbred Strains Receptors Cell Surface Biology CD8-Positive T-Lymphocytes Lymphocyte Activation Mice Mice Inbred AKR Immune system T-Lymphocyte Subsets Cause of Death medicine Concanavalin A Animals education education.field_of_study Lymphoblastic lymphoma Immunologic Deficiency Syndromes T lymphocyte Biological Sciences medicine.disease Mice Inbred C57BL medicine.anatomical_structure Hyaluronan Receptors Phenotype Mice Inbred DBA Immunology Interleukin-2 Female Carrier Proteins Immunologic Memory CD8 |
| Zdroj: | Journal of Gerontology |
| ISSN: | 0022-1422 |
| Popis: | We have assessed several age-sensitive indicators of immune status in young (i.e., 6 to 11-month-old) mice of a genetically heterogeneous population to see if these varied in parallel and to determine if one or more of the status indices predicted life span or cancer incidence. We report that the number of memory (i.e., CD44hi) T cells within the CD8 subset is correlated with number of memory cells in the CD4 population, and inversely correlated with the number of naive (i.e., CD45RBhi) CD4 cells at both 6 and 11 months of age, suggesting that the conversion of naive to memory cells may occur at similar rates in both T cell subsets. Mice that ranked high in the proportion of memory T cells (within the CD4 and CD8 pools) at 6 months of age tended to retain their ranking at 11 months, suggesting that the pace or extent of memory cell formation may be a consistent trait that distinguishes mice at least within a genetically heterogeneous population. Mice that at 6 months of age exhibited high levels ofCD4 or CD8 memory T cells, low levels of naive CD4 cells, or low levels of T cells able to proliferate in response to con a and 1l-2 were found to be significantly more likely than their littermates to die within the first 18 months of life. Cases offollicular cell lymphoma, lymphocytic and lymphoblastic lymphoma, and hepatic hemangiosarcoma were seen within the group of mice dying at early ages. Since each of the prognostic immune indices is characteristically seen in aged mice, we suggest that relatively precocious aging of the immune system may predispose a mouse to early death, particularly from lymphoma |
| Databáze: | OpenAIRE |
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