Pardinumones A–D: Antibacterial Polyketide–Amino Acid Derivatives from the Mushroom Tricholoma pardinum
| Autor: | Rong Huang, Jin-Tao Ma, Ji-Kai Liu, Zheng-Hui Li, Tao Feng, Hui-Xiang Yang, Juan He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Mushroom Circular dichroism biology Chemistry Stereochemistry General Chemical Engineering General Chemistry medicine.disease_cause biology.organism_classification Article Amino acid Polyketide Staphylococcus aureus Staphylococcus epidermidis medicine Antibacterial activity Escherichia coli QD1-999 |
| Zdroj: | ACS Omega, Vol 6, Iss 38, Pp 25089-25095 (2021) ACS Omega |
| ISSN: | 2470-1343 |
| Popis: | Four polyketide-amino acid derivatives, pardinumones A-D (1-4), were isolated from the wild mushroom Tricholoma pardinum. Their structures together with absolute configurations were characterized by means of spectroscopic data analyses, as well as calculated electronic circular dichroism (ECD) and NMR with sorted training set (STS) protocol analysis. Compounds 1-4 exhibited antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli with MIC values in the range of 6.25-50 μg/mL. |
| Databáze: | OpenAIRE |
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