A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men
| Autor: | Bernard M.Y. Cheung, GN Thomas, Annette W.K. Tso, C. Q. Jiang, Tai Hing Lam, Kwok Leung Ong, Pak C. Sham, Stacey S. Cherny, K. S. L. Lam |
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| Rok vydání: | 2010 |
| Předmět: |
Male
China medicine.medical_specialty Time Factors Blood viscosity Blood Pressure Single-nucleotide polymorphism Biology Fibrinogen Polymorphism Single Nucleotide Risk Assessment Linkage Disequilibrium Sex Factors Asian People Gene Frequency Risk Factors Internal medicine Odds Ratio Prevalence medicine Humans Genetic Predisposition to Disease Risk factor Allele frequency Fibrinogen beta chain Case-control study Hematology Odds ratio Logistic Models Phenotype Endocrinology Amino Acid Substitution Haplotypes Case-Control Studies Hypertension Linear Models Female Biomarkers medicine.drug |
| Zdroj: | Thrombosis and Haemostasis. 103:728-735 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th09-10-0692 |
| Popis: | SummaryFibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen β chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hyper-tension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 showed significant association with hypertension at both baseline (odds ratio [OR]=1.49, p=0.004) and at follow-up (OR=1.32, p=0.013). The minor A allele of this SNP was associated with higher plasma fibrinogen level (β=0.144, p |
| Databáze: | OpenAIRE |
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