Environmental exposures that affect the endocrine system: public health implications
| Autor: | Hana R. Pohl, Patricia Richter, Dennis Jones, C.T. DeRosa |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis Endocrine System Biology Environment Toxicology Affect (psychology) Bioinformatics Xenobiotics Human health chemistry.chemical_compound Structure-Activity Relationship Chemical mixtures Transgenerational epigenetics Internal medicine medicine Endocrine system Animals Humans Weight of evidence Public health Environmental Exposure Endocrinology Milk chemistry Body Burden Joints Public Health Xenobiotic Environmental Health Biomarkers |
| Zdroj: | Journal of toxicology and environmental health. Part B, Critical reviews. 1(1) |
| ISSN: | 1093-7404 |
| Popis: | In recent years much attention has been focused on the potential for a wide range of xenobiotic chemicals to interact with and disrupt the endocrine systems of animal and human populations. An overview of the chemicals that have been implicated as endocrine disruptors is presented. The ubiquity in the environment and associated body burdens of these chemicals in human populations are described. Potential mechanisms of action are reviewed, including the role of specific intracellular receptors and their interactions with endogenous and exogenous materials. The subsequent upregulation or downregulation of physiological processes at critical stages of development is discussed. The potential for joint toxic action and interaction of chemical mixtures is also discussed. The acknowledged role of wildlife populations as sentinels of potential human health effects is reviewed, and the weight of evidence for the role and impact of endocrine disruptors is presented. The implications of exposure to endocrine-disrupting chemicals for human health are reviewed, with special emphasis on the potential for transgenerational effects in at-risk populations. Recommendations for future research include the development of (1) structural activity and in vivo and in vitro functional toxicology methods to screen chemicals for their endocrine-disrupting ability, (2) biomarkers of exposure and effect, and (3) in situ sentinel systems. |
| Databáze: | OpenAIRE |
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