Do increases in deep grey matter volumes after electroconvulsive therapy persist in patients with major depression? A longitudinal MRI-study
| Autor: | Katrin Vogel, Daniela Pinter, Peter Hofmann, Anna K. Holl, Walter Wurm, Christian Enzinger, Hans-Peter Kapfhammer, Stefan Ropele, Margit Jehna, G. Fuchs, Hannes Deutschmann, Christoph Ebner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Grey matter behavioral disciplines and activities White matter 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Internal medicine mental disorders medicine Humans Gray Matter Electroconvulsive Therapy Depression (differential diagnoses) Depressive Disorder Major Depression business.industry Brain medicine.disease Magnetic Resonance Imaging 030227 psychiatry Peripheral Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Brain size Cohort Cardiology Major depressive disorder business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Affective Disorders. 281:908-917 |
| ISSN: | 0165-0327 |
| Popis: | Background Previous MRI studies reported deep grey matter volume increases after electroconvulsive therapy (ECT) in patients with major depressive disorder (MDD). However, the clinical correlates of these changes are still unclear. It remains debated whether such volume changes are transient, and if they correlate with affective changes over time. We here investigated if ECT induces deep grey matter volume increases in MDD-patients; and, if so, whether volume changes persist over more than 9 months and whether they are related to the clinical outcome. Methods We examined 16 MDD-patients with 3Tesla MRI before (baseline) and after an ECT-series and followed 12 of them up for 10-36 months. Patients’ data were compared to 16 healthy controls. Affective scales were used to investigate the relationship between therapy-outcome and MRI changes. Results At baseline, MDD-patients had lower values in global brain volume, white matter and peripheral grey matter compared to healthy controls, but we observed no significant differences in deep grey matter volumes. After ECT, the differences in peripheral grey matter disappeared, and patients demonstrated significant volume increases in the right hippocampus and both thalami, followed by subsequent decreases after 10-36 months, especially in ECT-responders. Controls did not show significant changes over time. Limitations Beside the relatively small, yet carefully characterized cohort, we address the variability in time between the third scanning session and the baseline. Conclusions ECT-induced deep grey matter volume increases are transient. Our results suggest that the thalamus might be a key region for the understanding of the mechanisms of ECT action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect