Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature
| Autor: | Alan Tennant, Rhiannon Edge, Carolyn A Young, Roger J Mills, Peter J. Diggle |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Quality of life
medicine.medical_specialty Section (typography) Pain Mistake Disease Anxiety 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Medicine 030212 general & internal medicine Amyotrophic lateral sclerosis (ALS) Amyotrophic lateral sclerosis Psychiatry Depression (differential diagnoses) Original Communication business.industry Depression TONiC study Motor neuron medicine.disease humanities medicine.anatomical_structure Neurology Motor neuron disease (MND) National study Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | Introduction The importance of elucidating the relationships between pain, mood and quality of life (QoL) amongst people with amyotrophic lateral sclerosis/motor neuron disease is evident to clinicians, yet the literature is limited and inconsistent. We explored the relationships between pain, depression, anxiety and QoL to reconcile the previous contrasting findings and inform future research and clinical practice. Methods Patient-reported outcomes were obtained as part of the Trajectories of Outcomes in Neurological Conditions study. Mood and QoL scales underwent Rasch analysis. Correlation coefficients examined the strength of association between variables of interest. A bivariate regression model was developed to examine the effects of pain, depression and anxiety on joint psychological and physical QoL domains. Results Of 636 people with ALS, 69% reported pain, of these most had mild pain. Seven percent (7%) of participants exceeded published cutoffs for probable depression and 14% had probable anxiety. Pain, depression and anxiety all influence quality of life; depression has a significant effect on both physical and psychological domains of QoL, whereas pain affects physical QoL and anxiety psychological QoL. Conclusions These results show the importance of expressing quality of life in a conceptually appropriate way, as failing to take account of the multidimensional nature of QoL can result in important nuances being overlooked. Clinicians must be aware that pain, depression and anxiety all worsen QoL across their ranges, and not just when pain is severe or when anxiety or depression reach case level. |
| Databáze: | OpenAIRE |
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