Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster
| Autor: | Vivian Ngan, Joel C. Eissenberg, T Hartnett, Sarah C. R. Elgin, Tharappel C. James, Dawn M. Foster-Hartnett |
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| Rok vydání: | 1990 |
| Předmět: |
Heterochromatin
Chromosomal Proteins Non-Histone Molecular Sequence Data Restriction Mapping Polymerase Chain Reaction Suppression Genetic Animals Amino Acid Sequence Cloning Molecular Alleles Variegation Gene Library Genetics Multidisciplinary biology Transition (genetics) Base Sequence Point mutation DNA Position-effect variegation biology.organism_classification Blotting Southern Position effect Drosophila melanogaster Chromobox Protein Homolog 5 Mutation Heterochromatin protein 1 Oligonucleotide Probes Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 87(24) |
| ISSN: | 0027-8424 |
| Popis: | We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects. |
| Databáze: | OpenAIRE |
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