Physicochemical Characterization of Physical Mixture and Solid Dispersion of Diclofenac Potassium with Mannitol
| Autor: | Gustavo Zitto, Adriana Ines Segall, Silvina L. Bonafede, Yong Han, María Ana Rosasco, Sonia Nerina Faudone |
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| Rok vydání: | 2017 |
| Předmět: |
CIENCIAS MÉDICAS Y DE LA SALUD
diclofenac potassium Inorganic chemistry Ciencias de la Salud Medicine (miscellaneous) 02 engineering and technology 030226 pharmacology & pharmacy purl.org/becyt/ford/3.3 [https] 03 medical and health sciences 0302 clinical medicine Differential scanning calorimetry Diclofenac Potassium medicine Pharmacology (medical) Dissolution testing General Pharmacology Toxicology and Pharmaceutics Micronization Dissolution Salud Ocupacional Chemistry mannitol 021001 nanoscience & nanotechnology Solvent stomatognathic diseases solid dispersio purl.org/becyt/ford/3 [https] Mannitol 0210 nano-technology Dispersion (chemistry) Nuclear chemistry medicine.drug |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| ISSN: | 2231-3354 |
| DOI: | 10.7324/japs.2017.70130 |
| Popis: | Diclofenac potassium is an anti-inflammatory agent classified as a class II drug as per the biopharmaceutical classification system (BCS). The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. There are several techniques to enhance the dissolution of poorly soluble drugs. Methods available include salt formation, micronization and addition of solvent or surface active agents. The objective of the present work is to improve the dissolution profile of diclofenac potassium by formation of a physical mixture and a solid dispersion with mannitol. The solid dispersion was prepared by solvent method using ethanol/water. As diclofenac potassium melts with decomposition, the compatibility study with mannitol was done with the acid form by differential scanning calorimetry (DSC). The dissolution properties and physicochemical properties of diclofenac potassium:mannitol physical mixture and solid dispersion were investigated by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and dissolution test. This study shows that the dissolution rate of diclofenac potassium can be enhanced considerably by formulating it with mannitol, as a physical mixture or as a solid dispersion although crystallinity was maintained. Fil: Han, Yong. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina Fil: Faudone, Sonia Nerina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina Fil: Zitto, Gustavo. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina Fil: Bonafede, Silvina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina Fil: Rosasco, María Ana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Control de Calidad de Medicamentos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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