Environment-Sensitive Nucleoside Probe Unravels the Complex Structural Dynamics of i-Motif DNAs

Autor:	Saddam Y. Khatik, Seergazhi G. Srivatsan
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Oligonucleotides Biomedical Engineering Humans Nucleic Acid Conformation Pharmaceutical Science Nucleosides Bioengineering DNA Deoxyuridine Fluorescent Dyes Biotechnology
Zdroj:	Bioconjugate Chemistry. 33:1515-1526
ISSN:	1520-4812 1043-1802
DOI:	10.1021/acs.bioconjchem.2c00237
Popis:	Although evidence for the existence and biological role of i-motif (iM) DNA structures in cells is emerging, probing their structural polymorphism and identifying physiologically active conformations using currently available tools remain a major challenge. Here, we describe the development of an innovative device to investigate the conformation equilibrium of different iMs formed by C-rich telomeric repeat and oncogenic
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cf5274bf38de2f10aedabcc92201c0 https://doi.org/10.1021/acs.bioconjchem.2c00237 Zobrazit plný text záznamu