Wolbachia strain wAlbB maintains high density and dengue inhibition following introduction into a field population of Aedes aegypti
| Autor: | Noor Afizah Ahmad, Ghazali M.R. Kamarul, W. A. Nazni, Steven P. Sinkins, Julien Martinez, Maria Vittoria Mancini, Ary A. Hoffmann, Thomas H. Ant |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
High density
vector control Aedes aegypti Dengue virus medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Dengue fever medicine virus blocking biology Strain (chemistry) wAlbB dengue virus Articles biology.organism_classification medicine.disease Virology Wolbachia General Agricultural and Biological Sciences Cytoplasmic incompatibility Research Article |
| Zdroj: | Philosophical Transactions of the Royal Society B: Biological Sciences |
| ISSN: | 1471-2970 0962-8436 |
| Popis: | Aedes aegyptimosquitoes carrying thewAlbBWolbachiastrain show a reduced capacity to transmit dengue virus.wAlbB has been introduced into wildAe. aegyptipopulations in several field sites in Kuala Lumpur, Malaysia, where it has persisted at high frequency for more than 2 years and significantly reduced dengue incidence. Although these encouraging results indicate thatwAlbB releases can be an effective dengue control strategy, the long-term success depends onwAlbB maintaining high population frequencies and virus transmission inhibition, and both could be compromised byWolbachia–host coevolution in the field. Here,wAlbB-carryingAe. aegypticollected from the field 20 months after the cessation of releases showed no reduction inWolbachiadensity or tissue distribution changes compared to awAlbB laboratory colony. ThewAlbB strain continued to induce complete unidirectional cytoplasmic incompatibility, showed perfect maternal transmission under laboratory conditions, and retained its capacity to inhibit dengue. Additionally, a field-collectedwAlbB line was challenged with Malaysian dengue patient blood, and showed significant blocking of virus dissemination to the salivary glands. These results indicate thatwAlbB continues to inhibit currently circulating strains of dengue in field populations ofAe. aegypti, and provides additional support for the continued scale-up ofWolbachiawAlbB releases for dengue control.This article is part of the theme issue ‘Novel control strategies for mosquito-borne diseases’. |
| Databáze: | OpenAIRE |
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