Sclerosis as a predictive factor for failure after bulbar urethroplasty: a prospective single-centre study
| Autor: | Ralph Peeker, Teresa Olsen Ekerhult, Lars Grenabo, Christina Kåbjörn Gustafsson, Klas Lindqvist |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urethral stricture Urology Urethroplasty medicine.medical_treatment 030232 urology & nephrology Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Urethra Fibrosis Recurrence medicine Humans Prospective Studies Treatment Failure Aged Proportional Hazards Models Urethral Stricture Sclerosis business.industry Histology Middle Aged Plastic Surgery Procedures medicine.disease Prognosis Predictive factor Surgery Single centre Nephrology 030220 oncology & carcinogenesis Histopathology business |
| Zdroj: | Scandinavian journal of urology. 52(4) |
| ISSN: | 2168-1813 |
| Popis: | The aim of this study was to assess whether sclerosis in histology following bulbar urethroplasty is a predictive factor for failure of surgery.Resected stricture specimens from 45 patients undergoing open urethroplasty with excision and anastomosis were collected prospectively during 2011-2014. Histopathological characteristics, including fibrosis (grade I-III), inflammation and sclerosis, were evaluated using different routine staining. These specimens were compared to normal urethral resection specimens from patients undergoing sex-correction surgery. The uropathologist who conducted the analyses was blinded to the study design.The outcomes of the histological classifications were as follows: 19 patients had grade I fibrosis, of whom three had failures; 13 patients had grade II fibrosis, without any failures; and the most severe fibrosis, grade III, including sclerosis, was found in 13 patients (11 with sclerosis), with failure in eight. Sclerosis was a significant risk factor for restricture when comparing patients with sclerosis and those without sclerosis, and likewise when adjusting for age, inflammation and stricture length.Histological findings of sclerosis in the resected urethral stricture specimen indicate a significantly higher risk for restricture after urethroplasty surgery. |
| Databáze: | OpenAIRE |
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