The Role of Nociceptin in Opioid Regulation of Brain Functions
| Autor: | P. K. Anokhin, I. Yu. Shamakina, V. S. Kohan, F. Sh. Shagiakhmetov, T. V. Davidova |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject Clinical Biochemistry Endogeny Anxiety Biochemistry General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Medicine Opioid peptide media_common business.industry Aggression Addiction Brain General Medicine Ligand (biochemistry) Analgesics Opioid Nociceptin receptor 030104 developmental biology Opioid Opioid Peptides Molecular Medicine medicine.symptom business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. 15:171-183 |
| ISSN: | 1990-7516 1990-7508 |
| Popis: | This review discusses our current knowledge on the nociceptin/orphanin (N/OFQ) system regarding its role in regulation of brain functions. Nociceptin receptor (NOPr) was identified in 1994 [Bunzow et al., 1994; Mollereau et al., 1994]. In 1995 a 17 amino acid endogenous peptide was found to be the high-affinity ligand for the NOPr [Reinscheid et al., 1995]. N/OFQ has a broad spectrum of activity and can act as on opioid-like as well as an anti-opioid peptide. Considering high level of N/OFQ and NOPr mRNA expression in the limbic brain regions, the N/OFQ/NOP system is suggested to be involved in regulation of emotions, resward, pain sensitivity, stress responsibility, sexual behavior, aggression, drug abuse and addiction. However it is still not well understood whether an increased vulnerability to drugs of abuse may be associated with dysregulation of N/OFQ/NOP system. Current review further highlights a need for further research on N/OFQ/NOP system as it could have clinical utility for substance abuse, depression, and anxiety pharmacotherapy.Obobshcheny aktual'nye literaturnye dannye o roli notsitseptina/orfanina v opioidnoĭ reguliatsii funktsiĭ nervnoĭ sistemy. Notsitseptinovyĭ retseptor (Nociceptin Opiate receptor, NOPr) byl vpervye opisan v 1994 godu (Bunzow i soav., 1994; Mollereau i soav., 1994). V 1995 godu byl otkryt éndogennyĭ ligand étogo retseptora — semnadtsatichlennyĭ peptid notsitseptin/orfanin FQ (Nociceptin/orphanin FQ, N/OFQ) (Reinscheid i soav., 1995), kotoryĭ otlichaetsia shirokim spektrom aktivnosti, proiavliaia kak pro-, tak i antiopioidnye svoĭstva. Vysokiĭ uroven' ékspressii N/OFQ i NOPr v limbicheskikh strukturakh mozga svidetel'stvuet o vovlechennosti N/OFQ v reguliatsiiu protsessov émotsional'nogo reagirovaniia, podkrepleniia, bolevoĭ chuvstvitel'nosti, stress-reaktivnosti, seksual'nogo povedeniia i agressii. Predpolagaiut, chto N/OFQ mozhet prinimat' aktivnoe uchastie v reguliatsii addiktivnogo povedeniia, odnako sviaz' predraspolozhennosti k zloupotrebleniiu psikhoaktivnymi veshchestvami s funktsional'nym sostoianiem notsitseptinovoĭ sistemy mozga do sikh por nedostatochno izuchena. Dal'neĭshie issledovaniia v étom napravlenii predstavliaiutsia ves'ma aktual'nymi i perspektivnymi pri razrabotke novykh sredstv farmakoterapii depressii, trevozhnykh rasstroĭstv, alkogol'noĭ i drugikh vidov zavisimosti. |
| Databáze: | OpenAIRE |
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