Risk of acute renal failure and mortality after surgery for a fracture of the hip
| Autor: | Alma B Pedersen, Henrik Toft Sørensen, Christian Fynbo Christiansen, Johnny Kahlert, Henrik Gammelager |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Denmark 030209 endocrinology & metabolism Kaplan-Meier Estimate 03 medical and health sciences Population based cohort Postoperative Complications 0302 clinical medicine Risk Factors Journal Article medicine Humans Orthopedics and Sports Medicine Prospective Studies 030212 general & internal medicine Stage (cooking) Prospective cohort study Aged Hip fracture Hip Fractures business.industry Hazard ratio Acute kidney injury Acute Kidney Injury medicine.disease Confidence interval Surgery Female business Kidney disease |
| Zdroj: | Pedersen, A B, Christiansen, C F, Gammelager, H, Kahlert, J A & Sørensen, H T 2016, ' Risk of acute renal failure and mortality after surgery for a fracture of the hip : a population-based cohort study ', Journal of Bone and Joint Surgery: British Volume, vol. 98-B, no. 8, pp. 1112-8 . https://doi.org/10.1302/0301-620X.98B8.37497 |
| ISSN: | 2049-4408 2049-4394 |
| DOI: | 10.1302/0301-620x.98b8.37497 |
| Popis: | Aims We examined risk of developing acute renal failure and the associated mortality among patients aged > 65 years undergoing surgery for a fracture of the hip. Patients and Methods We used medical databases to identify patients who underwent surgical treatment for a fracture of the hip in Northern Denmark between 2005 and 2011. Acute renal failure was classified as stage 1, 2 and 3 according to the Kidney Disease Improving Global Outcome criteria. We computed the risk of developing acute renal failure within five days after surgery with death as a competing risk, and the short-term (six to 30 days post-operatively) and long-term mortality (31 days to 365 days post-operatively). We calculated adjusted hazard ratios (HRs) for death with 95% confidence intervals (CIs). Results Among 13 529 patients who sustained a fracture of the hip, 1717 (12.7%) developed acute renal failure post-operatively, including 1218 (9.0%) with stage 1, 364 (2.7%) with stage 2, and 135 (1.0%) with stage 3 renal failure. The short-term mortality was 15.9% and 5.6% for patients with and without acute renal failure, respectively (HR 2.8, 95% CI 2.4 to 3.2). The long-term mortality was 25.0% and 18.3% for those with and without acute renal failure, respectively (HR 1.3, 95% CI 1.2 to 1.5). The mortality was higher in patients with an increased severity of renal failure. Conclusion Acute renal failure is a common complication of surgery in elderly patients who sustain a fracture of the hip, and is associated with increased mortality up to one year after surgery despite adjustment for coexisting comorbidity and medication before surgery. Cite this article: Bone Joint J 2016;98-B:1112–18. |
| Databáze: | OpenAIRE |
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