CD4(+)CD25(high)CD127(low) regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation
| Autor: | A V Potekhina, V P Masenko, E A Pylaeva, T. L. Krasnikova, N. B. Kukhtina, Tatiana I. Arefieva, E.A. Noeva, S I Provatorov, Vladimir O. Sokolov |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male medicine.medical_specialty Angioplasty Balloon Laser-Assisted Time Factors Immunology chemical and pharmacologic phenomena Stable angina T-Lymphocytes Regulatory Angina Pectoris Interleukin-7 Receptor alpha Subunit Risk Factors Internal medicine medicine Immunology and Allergy Stent implantation Humans Immunologic Factors In patient cardiovascular diseases IL-2 receptor Angioplasty Balloon Coronary Interleukin-7 receptor Coronary atherosclerosis Aged Sirolimus business.industry Interleukin-2 Receptor alpha Subunit Coronary stenting hemic and immune systems Drug-Eluting Stents General Medicine Middle Aged Lymphocyte Subsets C-Reactive Protein Cardiology Female business medicine.drug |
| Zdroj: | Human immunology. 72(7) |
| ISSN: | 1879-1166 |
| Popis: | Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro . We investigated CD4 + CD25 high CD127 low Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) with sirolimus (rapamycin)-eluting stents (SES; n = 43). The relation between initial Treg values and the severity of coronary atherosclerosis was observed. Treg and sCD25 levels were increased 1 month after CS versus baseline values and versus data in the control group (coronary angiography [CA], n = 20). A positive correlation between Treg and sCD25 levels was reported, whereas no relation was observed with the length of SES implanted. HsCRP level was increased during the first 7 days and returned to baseline values 1 month after CS/CA. Treg content is lower in patients with multivessel CAD. Elevated levels of Tregs and sCD25 after SES implantation might occur because of the immunomodulating effect of rapamycin. |
| Databáze: | OpenAIRE |
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