Evidence of Specialized Conduction Cells in Human Pulmonary Veins of Patients with Atrial Fibrillation

Autor:	James T. McMahon, A. Marc Gillinov, Robert A. Schweikert, Patrick M. McCarthy, Norman B. Ratliff, Walid I. Saliba, Nassir F. Marrouche, Andrea Natale, Patrick Tchou, José L. Navia, Alejandro Perez-Lugones, Eduardo B. Saad
Rok vydání:	2003
Předmět:	Adult Male Pathology medicine.medical_specialty Adolescent Isolation procedures Autopsy Pulmonary vein law.invention Heart Conduction System law Physiology (medical) Atrial Fibrillation Cadaver medicine Humans Myocytes Cardiac Sinus (anatomy) Aged Sinoatrial Node Aged 80 and over business.industry Atrial fibrillation Atrial arrhythmias Middle Aged medicine.disease medicine.anatomical_structure Pulmonary Veins cardiovascular system Transitional Cell Female Electron microscope Cardiology and Cardiovascular Medicine business
Zdroj:	Journal of Cardiovascular Electrophysiology. 14:803-809
ISSN:	1540-8167 1045-3873
DOI:	10.1046/j.1540-8167.2003.03075.x
Popis:	Introduction: Depolarizations similar to those from the sinus node have been documented from the pulmonary veins after isolation procedures. We assessed the hypothesis that sinus node-like tissue is present in the pulmonary veins of humans. Methods and Results: Pulmonary vein tissue was obtained from five autopsies (four individuals with a history of atrial fibrillation and one without a history of atrial arrhythmias) and five transplant heart donors. Autopsy veins were fixed in formaldehyde and processed for light microscopy to identify areas having possible conductive-like tissue. Areas requiring additional study were extracted from paraffin blocks and reprocessed for electron microscopy. Donor specimens were fixed in formaldehyde for histologic sections and glutaraldehyde for electron microscopy. Myocardial cells with pale cytoplasm were identified by light microscopy in 4 of the 5 autopsy subjects. Electron microscopy confirmed the presence of P cells, transitional cells, and Purkinje cells in the pulmonary veins of these cases. Conclusion: Our report is the first to show the presence of P cells, transitional cells, and Purkinje cells in human pulmonary veins. Whether these cells are relevant in the genesis of atrial fibrillation requires further study. (J Cardiovasc Electrophysiol, Vol. 14, pp. 803-809, August 2003)
Databáze:	OpenAIRE
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