Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank
| Autor: | Erin L. Richard, Linda K. McEvoy, Ian J. Deary, Gail Davies, Steven Y. Cao, Eyal Oren, John E. Alcaraz, Andrea Z. LaCroix, Jan Bressler, Rany M. Salem |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Kidney Disease glomerular fltration rate cognitive aging Clinical Sciences Renal and urogenital Genetic Variation Urology & Nephrology Kidney United Kingdom Cross-Sectional Studies Cognition Nephrology Clinical Research Creatinine Behavioral and Social Science Humans Albuminuria abuminuria Female polygenic score Cystatin C Glomerular filtration rate Biomarkers Biological Specimen Banks |
| Zdroj: | Richard, E L, Mcevoy, L K, Deary, I J, Davies, G, Cao, S Y, Oren, E, Alcaraz, J E, Lacroix, A Z, Bressler, J & Salem, R M 2022, ' Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank ', BMC Nephrology, vol. 23, 159 . https://doi.org/10.1186/s12882-022-02750-6 BMC nephrology, vol 23, iss 1 |
| DOI: | 10.1186/s12882-022-02750-6 |
| Popis: | Background Chronic kidney disease has been linked to worse cognition. However, this association may be dependent on the marker of kidney function used, and studies assessing modification by genetics are lacking. This study examined associations between multiple measures of kidney function and assessed effect modification by a polygenic score for general cognitive function. Methods In this cross-sectional study of up to 341,208 European ancestry participants from the UK Biobank study, we examined associations between albuminuria and estimated glomerular filtration rate based on creatinine (eGFRcre) or cystatin C (eGFRcys) with cognitive performance on tests of verbal-numeric reasoning, reaction time and visual memory. Adjustment for confounding factors was performed using multivariate regression and propensity-score matching. Interaction between kidney function markers and a polygenic risk score for general cognitive function was also assessed. Results Albuminuria was associated with worse performance on tasks of verbal-numeric reasoning (β(points) = -0.09, p p p = 0.01). A polygenic score for cognitive function modified the association between albuminuria and verbal-numeric reasoning with significantly lower scores in those with albuminuria and a lower polygenic score (p = 0.009). Compared to participants with eGFRcre ≥ 60 ml/min, those with eGFRcre p p p p Conclusions Increased urine albumin is associated with worse cognition, but this may depend on genetic risk. Cystatin C-based eGFR may better predict cognitive performance than creatinine-based estimates. |
| Databáze: | OpenAIRE |
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