Purification, crystallization and preliminary X-ray studies ofMycobacterium tuberculosisRRF
| Autor: | M. Bidya Sagar, A. R. Rao, Kayarat Saikrishnan, Mamannamana Vijayan, S. K. Kalapala, Umesh Varshney |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Ribosomal Proteins
Genetics Whole genome sequencing Tuberculosis Protein Conformation Ribosome Recycling Factor Proteins Mycobacterium tuberculosis General Medicine Biology Crystallography X-Ray medicine.disease biology.organism_classification Protein Structure Tertiary Molecular level Structural Biology biology.protein medicine Electrophoresis Polyacrylamide Gel Crystallization |
| Zdroj: | Acta Crystallographica Section D Biological Crystallography. 60:368-370 |
| ISSN: | 0907-4449 |
| DOI: | 10.1107/s0907444903027926 |
| Popis: | With the re-emergence of tuberculosis providing the impetus, research on Mycobacterium tuberculosis at the molecular level has registered considerable progress in recent years (Ratledge & Dale, 1999). In particular, the availability of the complete genome sequence of the pathogen has facilitated such research (Cole et al., 1998). The sequence indicates the presence of about 4000 tuberculosis proteins, but the three-dimensional structures of only a few dozen of them are currently known. As part of a continuing effort in this laboratory to characterize the structures of these proteins (Datta et al., 2000, 2003; Saikrishnan et al., 2003), the crystallization and preliminary studies of the ribosome recycling factor (RRF) from this organism have been carried out. |
| Databáze: | OpenAIRE |
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