PD-L1 expression and overall survival in Asian and western patients with gastric cancer

Autor:	Sun Young Rha, Geoffrey Y Ku, Hyo Song Kim, Hyun Cheol Chung, Fatemeh Ghazanfari Amlashi, Dipen Maheshbhai Maru, Carly A Fein, Laura H Tang, Wei Zhou, Ting Wu, Senaka A Peter, David P Kelsen, Jaffer A Ajani
Rok vydání:	2022
Předmět:	Cancer Research Oncology Stomach Neoplasms Biomarkers Tumor Humans General Medicine B7-H1 Antigen Retrospective Studies
Zdroj:	Future Oncology. 18:2623-2634
ISSN:	1744-8301 1479-6694
DOI:	10.2217/fon-2022-0103
Popis:	Aim: Data are limited on PD-L1 expression and its association with overall survival (OS) in gastric cancer (GC) patients receiving routine care in different regions. Materials & methods: In a retrospective study, PD-L1 expression was assayed using the 22C3 pharmDx on GC tumor samples collected between 2003 and 2017 at South Korean and US cancer centers. PD-L1 positivity was defined as combined positive score (CPS) ≥1. The relationship between PD-L1 and OS was analyzed. Results: Of 574 GC tumor samples, 67.4% were CPS ≥1 (68.7% in Korean and 65.7% in US patients). PD-L1 expression was not associated with OS (adjusted hazard ratio: 0.94; 95% CI: 0.75–1.17). Conclusion: PD-L1 prevalence and its association with OS was similar between South Korean and US GC patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c190924e7155d5c352531bd98ae59f https://doi.org/10.2217/fon-2022-0103 Zobrazit plný text záznamu