Inflammatory patterns in upper airway disease in the same geographical area may change over time
| Autor: | Vassilios Danielides, Gabriele Holtappels, Soranart Muangsomboon, Claude Cuvelier, Thibaut Van Zele, Chaweewan Bunnag, Michael Katotomichelakis, Nan Zhang, Claus Bachert, Perapun Jareonchasri, Lan Feng, Peter Hellings, Pongsakorn Tantilipikorn, Natalie De Ruyck |
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| Přispěvatelé: | Ear, Nose and Throat |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Change over time Staphylococcus aureus Neutrophils Chronic rhinosinusitis 03 medical and health sciences Nasal Polyps 0302 clinical medicine Humans Immunology and Allergy Medicine Nasal polyps Sinusitis 030223 otorhinolaryngology Rhinitis Asthma Inflammation business.industry Interleukin-17 General Medicine Immunoglobulin E Middle Aged Staphylococcal Infections Thailand medicine.disease Bacterial Load Inflammatory mediator Eosinophils Chronic disease 030228 respiratory system Otorhinolaryngology Chronic Disease Immunology Female Inflammation Mediators Interleukin-5 business Upper airway disease Follow-Up Studies |
| Zdroj: | American journal of rhinology & allergy, 27(5), 354-360. OceanSide Publications Inc. American Journal of Rhinology and Allergy; Vol 27 |
| ISSN: | 1945-8932 |
| Popis: | Background Inflammatory patterns of nasal polyps (NPs) may vary. Changes over time have not been investigated so far. This study was designed to evaluate the inflammatory patterns of NPs in Thailand at two time points 12 years apart, explore differences in Staphylococcus aureus (SA) mucosal carriage rates over time, and the latter's relationship with the inflammatory patterns. Methods Formalin-fixed nasal tissue was obtained from 89 (47 in 1999 and 42 in 2011) patients suffering from chronic rhinosinusitis with NPs (CRSwNPs). Tissues were evaluated for eosinophils, neutrophils, IgE+ cells, IgE and macrophage mannose receptors, interleukin (IL)-5 and IL-17 cytokine profile, and the presence of SA, using automated immunohistochemistry and peptide nucleic acid–fluorescence in situ hybridization. Results We found a significant increase in the absolute values of eosinophils and IgE+ cells in the 2011 CRSwNP tissue series compared with 1999 and a significant but smaller increase in neutrophils. Semiquantitative evaluation revealed significantly higher mean values of positive cells for all studied inflammatory markers in the 2011 group of patients, except for the high-affinity IgE receptor. This “eosinophilic shift” of inflammation was accompanied by higher SA carriage, as well as higher frequencies of SA invasion (54.8% versus 10.6%; p < 0.001) in the 2011 compared with 1999 subjects. Patients with asthma were more likely to have higher SA carriage rates compared with nonasthmatic patients. Conclusion There was a shift from predominantly neutrophilic to eosinophilic CRSwNPs in Thai patients within 12 years, with an increase in various inflammatory markers including IgE, which is associated with an increase in intramucosal presence of SA. |
| Databáze: | OpenAIRE |
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