Influence of serum 25-hydroxyvitamin D levels, fat-free mass, and fat mass on bone density, geometry and strength, in healthy young and elderly adults
| Autor: | Egle Perissinotto, Giuseppe Sergi, Marco Bedogni, Sabrina Pigozzo, Francesca Piovesan, Marta Dianin, Martina Zaninotto, Enzo Manzato, Giulia Bano, Mattia Mazzochin, Mario Plebani, Sandro Giannini |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Bone parameters medicine.medical_specialty Aging Bone density 030209 endocrinology & metabolism Elderly people Body composition Biochemistry Fat mass 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Endocrinology Bone Density Internal medicine medicine Genetics Humans Longitudinal Studies 030212 general & internal medicine Tibia Elderly adults Vitamin D Young adult Serum 25 hydroxyvitamin d pQCT Molecular Biology Aged 25-OHD business.industry Young adults Cell Biology Middle Aged Healthy Volunteers Radius Cross-Sectional Studies medicine.anatomical_structure Female Cortical bone Tomography X-Ray Computed business |
| Popis: | Purpose The association between serum 25-hydroxyvitamin D (25-OHD) levels and cortical/trabecular bone parameters has been explored in the elderly, but less so in younger adults; body composition may also influence bone parameters across the life span. We aimed to investigate, with peripheral quantitative computerized tomography (pQCT), the relationship between serum 25-OHD levels and bone geometry and strength and, at the same time, to explore the influence of fat mass and fat-free mass on bone parameters, for the tibia and radius, in healthy young and elderly adults. Methods The study involved 149 healthy adults grouped by age: 65 were under 65 years old, and 84 were older. All participants were assessed in terms of: clinical history; serum 25-OHD levels; fat-free mass (FFM) and fat mass (FM), measured with DXA; total and cortical bone cross-sectional area (CSA, CSAc), and trabecular and cortical bone mineral density (BMDt, BMDc); and fracture load x and y for the tibia and radius, measured with pQCT. Results In the younger group, the association between 25-OHD levels and bone parameters did not remain as significant for any parameters after multivariate adjustment. In the elderly, 25-OHD correlated with CSAc (partial R2 = 0.33), fracture load x (partial R2 = 0.54), and fracture load y (partial R2 = 0.46) for the radius, and marginally with BMDt (partial R2 = 0.09; B-H adjusted p Conclusion While serum 25-OHD levels correlated only weakly with bone parameters in younger adults, a significant relationship was observed for elderly people. Fat-free mass showed positive simple correlation with pQCT-derived bone parameters in both age groups except with BMDc in the younger group. Further longitudinal studies are needed to clarify these relationships. |
| Databáze: | OpenAIRE |
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