Lanolin-Based Synthetic Membranes for Transdermal Permeation and Penetration Drug Delivery Assays

Autor: Clara Barba, Luisa Coderch, Meritxell Martí, Ilaria Collini, Cristina Alonso
Přispěvatelé: Martí, Meritxell [0000-0001-9681-6466], Martí, Meritxell
Rok vydání: 2021
Předmět:
Zdroj: Membranes
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Volume 11
Issue 6
Membranes, Vol 11, Iss 444, p 444 (2021)
ISSN: 2077-0375
Popis: Due to the high similarity in composition and structure between lanolin and human SC lipids, we will work with two models from wool wax. Two types of lanolin were evaluated: one extracted with water and surfactants (WEL) and the other extracted with organic solvents (SEL). Skin permeation and skin penetration studies were performed with two active compounds to study the feasibility of the use of lanolin-based synthetic membranes as models of mammalian skin. Diclofenac sodium and lidocaine were selected as the active compounds considering that they have different chemical natures and different lipophilicities. In the permeation assay with SEL, a better correlation was obtained with the less permeable compound diclofenac sodium. This assay suggests the feasibility of using artificial membranes with SEL as a model for percutaneous absorption studies, even though the lipophilic barrier should be improved. Penetration profiles of the APIs through the SEL and WEL membranes indicated that the two membranes diminish penetration and can be considered good membrane surrogates for skin permeability studies. However, the WEL membranes, with a pH value similar to that of the skin surface, promoted a higher degree of diminution of the permeability of the two drugs, similar to those found for the skin.
The present work could not be performed without the collaboration and contribution of the Service of Dermocosmetic Assessment from IQAC-CSIC. The authors are also grateful to Montserrat Rigol Muxart and Núria Solanes Batlló from the Department of Cardiology (Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS) Hospital Clínic, Universitat de Barcelona, Spain) for supplying the porcine skin biopsies. This work was partially supported by Ministerio de Ciencia, Innovación y Universidades, España (number CTQ2018-094014-B-100) and by the Consejo Superior de Investigaciones Científicas (CSIC-COV19-130).
Databáze: OpenAIRE
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