Role of adipokines and inflammatory markers in postmenopausal hypertension
| Autor: | Todd Gress, Saba Faiz, Henry K. Driscoll, Omolola Olajide, Nalini Santanam, Abid Yaqub, Ronald J. Stanek, Prasanna Santhanam, Mose July, Jillian Douglas |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Endocrinology Diabetes and Metabolism Adipokine Physiology Blood Pressure 030204 cardiovascular system & hematology 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Endocrinology Waist–hip ratio Adipokines Internal Medicine Medicine Humans Obesity Aged Adiponectin business.industry Waist-Hip Ratio Significant difference Anthropometry Middle Aged Serum samples medicine.disease Postmenopause Blood pressure Premenopause Hypertension Female Inflammation Mediators business Biomarkers |
| Zdroj: | Minerva endocrinologica. 43(2) |
| ISSN: | 1827-1634 |
| Popis: | BACKGROUND The role of inflammatory markers and adipokines contributing to the development of postmenopausal hypertension, has not been established. The aim of our study was to assess the complex association between blood pressure, obesity, menopausal status, adipokines and inflammatory mediators in postmenopausal women. METHODS We recruited 38 women seen at our Endocrinology Clinic and collected anthropometric measures and blood pressure and obtained serum samples for inflammatory markers and adipokine levels. Out of 38 women, 23 (60%) were postmenopausal. RESULTS In the pre-menopausal and postmenopausal women, there were no significant differences in measured adipokines and inflammatory markers based on hypertensive status. When obesity was eliminated, significantly higher levels of EGF, IL-8, MCP1 and TNF-α and lower levels of IL-1α and IL-3 were observed in the postmenopausal group (P |
| Databáze: | OpenAIRE |
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