Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy
| Autor: | Val J. Lowe, Matthew L. Senjem, Jennifer L. Whitwell, Farwa Ali, Hugo Botha, Robert I. Reid, Peter R. Martin, Kenton R. Kaufman, Stacy R. Loushin, Keith A. Josephs, Christopher G. Schwarz, Clifford R. Jack, Irene Sintini |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
PSP-P
progressive supranuclear palsy – parkinsonism MCP middle cerebellar peduncle FDG fluorodeoxyglucose ROI region of interest SFO superior fronto-occipital fasciculus CGC cingulate gyrus CTS corticospinal tract Corpus callosum Postural imbalance EC postural imbalance with eyes closed Postural imbalance EO postural imbalance with eyes open Gait (human) RMSE root mean square error EC external capsule SLF superior longitudinal fasciculus PSP – SL progressive supranuclear palsy – speech and language FA fractional anisotropy Gait CGH cingulum (hippocampus) Regular Article Magnetic Resonance Imaging SUVR standard uptake value ratios Superior cerebellar peduncle medicine.anatomical_structure Diffusion Tensor Imaging Neurology PSP progressive supranuclear palsy PLS partial least square Supranuclear Palsy Progressive PSP-PGF progressive supranuclear palsy – progressive freezing of gait SCC splenium of the corpus callosum MRI Balance medicine.medical_specialty GCC genu of the corpus callosum Cognitive Neuroscience Computer applications to medicine. Medical informatics SCP superior cerebellar peduncle R858-859.7 Splenium Neuroimaging CP cerebral peduncle xCOM extrapolated center of mass Progressive supranuclear palsy White matter PCR posterior corona radiata Physical medicine and rehabilitation SCR superior corona radiata medicine Humans Radiology Nuclear Medicine and imaging MDS - UPDRS Movement Disorder Society - sponsored revision of the Unified Parkinson’s Disease Rating Scale ACR anterior corona radiata SS sagittal stratum RC346-429 COP center of pressure MD mean diffusivity PLIC posterior limb of internal capsule PSP-RS progressive supranuclear palsy – Richardson’s syndrome PCA principal component analysis ML medial lemniscus business.industry Precentral gyrus CV coefficient of variation PSP-CBS progressive supranuclear palsy – corticobasal syndrome PC principal component PCT pontine crossing tract BCC body of the corpus callosum medicine.disease eye diseases BoS base of support PET ALIC anterior limb of internal capsule Corticospinal tract PTR posterior thalamic radiation RLIC retrolenticular part of internal capsule Neurology. Diseases of the nervous system Neurology (clinical) DTI diffusion tensor imaging business human activities ICP inferior cerebellar peduncle |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 32, Iss, Pp 102850-(2021) |
| ISSN: | 2213-1582 |
| Popis: | Highlights • Gait and balance impairments correlated to various imaging abnormalities. • Stride length, cadence and balance varied independently in PSP. • PSP phenotype affects the associations between gait and imaging. Progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex. Neurodegenerative change in progressive supranuclear palsy has been assessed using MRI. Degeneration of white matter tracts is evident with diffusion tensor imaging and PET methods have been used to assess brain metabolism or presence of tau protein deposits. Patients with progressive supranuclear palsy present with a variety of clinical syndromes; however early onset of gait impairments and postural instability are common features. In this study we assessed the relationship between multimodal imaging biomarkers (i.e., MRI atrophy, white matter tracts degeneration, flortaucipir-PET uptake) and laboratory-based measures of gait and balance abnormalities in a cohort of nineteen patients with progressive supranuclear palsy, using univariate and multivariate statistical analyses. The PSP rating scale and its gait midline sub-score were strongly correlated to gait abnormalities but not to postural imbalance. Principal component analysis on gait variables identified velocity, stride length, gait stability ratio, length of gait phases and dynamic stability as the main contributors to the first component, which was associated with diffusion tensor imaging measures in the posterior thalamic radiation, external capsule, superior cerebellar peduncle, superior fronto-occipital fasciculus, body and splenium of the corpus callosum and sagittal stratum, with MRI volumes in frontal and precentral regions and with flortaucipir-PET uptake in the precentral gyrus. The main contributor to the second principal component was cadence, which was higher in patients presenting more abnormalities on mean diffusivity: this unexpected finding might be related to compensatory gait strategies adopted in progressive supranuclear palsy. Postural imbalance was the main contributor to the third principal component, which was related to flortaucipir-PET uptake in the left paracentral lobule and supplementary motor area and white matter disruption in the superior cerebellar peduncle, putamen, pontine crossing tract and corticospinal tract. A partial least square model identified flortaucipir-PET uptake in midbrain, basal ganglia and thalamus as the main correlate of speed and dynamic component of gait in progressive supranuclear palsy. Although causality cannot be established in this analysis, our study sheds light on neurodegeneration of brain regions and white matter tracts that underlies gait and balance impairment in progressive supranuclear palsy. |
| Databáze: | OpenAIRE |
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