SOMATOSENSORY EVOKED POTENTIAL AND HISTOPATHOLOGICAL INVESTIGATIONS IN ISCHAEMIA-INDUCED BRAIN DAMAGE: EFFECTS OF TRIMETAZIDINE IN RATS

Autor: Tülay Kurt, Atilla Oguzhanoglu, Ragip Ortaç, Bulent Turman
Rok vydání: 2003
Předmět:
hippocampus
Evoked potential
Vasodilator Agents
Hippocampus
Hippocampal formation
Pharmacology
Brain Ischemia
Rats
Sprague-Dawley
rat
Cell Death
General Neuroscience
s 5016
drug effect
article
Animals
Brain Ischemia/*drug therapy/pathology/physiopathology
Cell Death/drug effects
Chi-Square Distribution
Disease Models
Animal
Evoked Potentials
Somatosensory/*drug effects
Hippocampus/drug effects/pathology/physiopathology
Neuroprotective Agents/*pharmacology
Rats
Reperfusion Injury/prevention & control
Statistics
Nonparametric
Trimetazidine/*pharmacology
Vasodilator Agents/pharmacology
General Medicine
reperfusion injury
Neuroprotective Agents
medicine.anatomical_structure
Anesthesia
histopathology
neuroprotection
medicine.symptom
medicine.drug
trimetazidine
animal experiment
Central nervous system
Trimetazidine
Ischemia
Brain damage
animal tissue
Evoked Potentials
Somatosensory
medicine
controlled study
Cell damage
nonhuman
business.industry
animal model
evoked somatosensory response
medicine.disease
cell damage
Somatosensory evoked potential
Global ischaemia
business
Zdroj: International Journal of Neuroscience. 113:447-454
ISSN: 1543-5245
0020-7454
DOI: 10.1080/00207450390162209
Popis: We studied the protective effects of trimetazidine (TMZ) on brain damage by means of somatosensory evoked potentials (SEP) in rats. The TMZ group did not show any statistically significant difference from the control group with respect to SEPs. However, the percentage of cells with ischaemic cell damage in hippocampal regions was significantly smaller in the TMZ group than the control group. Trimetazidine reduced the number of damaged cells in the cerebral tissue during the ischaemia-reperfusion damage. It was suggested that higher doses of trimetazidine may further reduce the number of cells with ischaemic damage.
Databáze: OpenAIRE
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