Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition
| Autor: | Michael J. Dawson, P. A. Chalk, H. M. Noble, Howard G. Wildman, C. Stylli, M. V. Hayes, Brian A. M. Rudd, B. Lamont, A. Shuttleworth, H. C. Jackson, Oonagh S. Kinsman, S. Lynn, Carol A. Jones, Philip J. Sidebottom, R. F. Middleton |
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| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
Cryptococcus neoformans Protein Synthesis Inhibitors Protein synthesis inhibitor Antifungal Agents biology medicine.drug_class Antifungal antibiotic Antibiotics Biological activity Fungi imperfecti Microbial Sensitivity Tests biology.organism_classification Corpus albicans Microbiology Mice Aspergillus Drug Discovery Candida albicans Fermentation medicine Animals Polycyclic Compounds Mitosporic Fungi |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0021-8820 |
| Popis: | A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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