A New Subfamily of the Nudix Hydrolase Superfamily Active on 5-Methyl-UTP (Ribo-TTP) and UTP
| Autor: | JianYing Shen, Maurice J. Bessman, WenLian Xu, Christopher A. Dunn |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Subfamily
Upstream and downstream (transduction) Molecular Sequence Data Uridine Triphosphate Biology Biochemistry Nudix hydrolase Substrate Specificity Caulobacter chemistry.chemical_compound heterocyclic compounds Nucleotide Amino Acid Sequence Cloning Molecular Pyrophosphatases Molecular Biology Gene Genetics chemistry.chemical_classification Cell Biology Amino acid Enzyme chemistry Agrobacterium tumefaciens Pseudomonas aeruginosa Nucleoside triphosphate |
| Zdroj: | Journal of Biological Chemistry. 278:37492-37496 |
| ISSN: | 0021-9258 |
| Popis: | A new subfamily of the Nudix hydrolases, identified by conserved amino acids upstream and downstream of the Nudix box, has been characterized. The cloned, expressed, and purified orthologous enzymes have major activities on the non-canonical nucleoside triphosphate 5-methyl-UTP (ribo-TTP) and the canonical nucleotide UTP. In addition to their homologous signature sequences and their similar substrate specificities, the members of the subfamily are inhabitants of or are related to the bacterial rhizosphere. We propose the acronym and mnemonic, utp, for the gene designating this unique UTPase. |
| Databáze: | OpenAIRE |
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