Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

Autor: Nessa Hawkins, Anne Colombero, Colin R. Dunstan, John M. Delaney, Steve Kaufman, Tim Burgess, S. Scully, E. Davy, Victoria Shalhoub, Robin Elliott, Giorgio Senaldi, Hailing Hsu, Jane Guo, John K. Sullivan, Hong-Lin Tan, Gary Elliott, Michael J. Kelley, Ildiko Sarosi, William J. Boyle, C. Capparelli, Emma Timms, David L. Lacey, Alana Eli, Yi-xin Qian
Rok vydání: 1998
Předmět:
musculoskeletal diseases
medicine.medical_specialty
Stromal cell
Recombinant Fusion Proteins
Cellular differentiation
Molecular Sequence Data
Osteoclasts
Receptors
Cytoplasmic and Nuclear
Osteoclast fusion
Ligands
Receptors
Tumor Necrosis Factor
General Biochemistry
Genetics and Molecular Biology
Osteoclast maturation
Mice
Osteoprotegerin
Osteoclast
Internal medicine
medicine
Animals
Humans
Amino Acid Sequence
RNA
Messenger
Bone Resorption
Cloning
Molecular
Cells
Cultured
Glycoproteins
Membrane Glycoproteins
Receptor Activator of Nuclear Factor-kappa B
biology
Biochemistry
Genetics and Molecular Biology(all)
Macrophage Colony-Stimulating Factor
RANK Ligand
Gene Expression Regulation
Developmental
Cell Differentiation
Hematopoietic Stem Cells
Coculture Techniques
Rats
Cell biology
Endocrinology
medicine.anatomical_structure
Organ Specificity
RANKL
Hypercalcemia
biology.protein
Cytokines
Carrier Proteins
Protein Binding
Zdroj: Cell. 93:165-176
ISSN: 0092-8674
Popis: The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development.
Databáze: OpenAIRE
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