Neuropharmacological and behavioral evaluation of prostaglandin E2 and 11-thiol-11-desoxy prostaglandin E2 in the mouse and rat
| Autor: | James L. Bloss, Garry H. Singer |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Prostaglandins E Synthetic Fluphenazine Physostigmine Dextroamphetamine Thioridazine Motor Activity Pharmacology Catalepsy Mice Avoidance Learning medicine Haloperidol Animals Humans Prostaglandin E2 Clozapine Behavior Animal Chemistry Prostaglandins E medicine.disease Rats Stereotyped Behavior Antagonism medicine.drug |
| Zdroj: | Psychopharmacology. 57:295-302 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00426754 |
| Popis: | Prostaglandin E2 (PGE2) and 11-thiol-11-desoxy Prostaglandin E2 (SHPGE2) were evaluated in a variety of behavioral and neuropharmacological procedures that are sensitive to neuroleptics. Clozapine (C), thioridazine (T), haloperidol (H), and fluphenazine (F) were also tested for comparison. All agents except T suppressed avoidance responses in trained rats at one or more doses without concurrently disrupting escape behavior. T, H, and F dose-responsively antagonized lesioned rat rotational behavior at nontoxic doses. T, H, and F induced catalepsy at doses considerably higher than those effective on rotational behavior. SHPGE2, PGE2, and C did not cause catalepsy and did not show statistically significant dose-response antagonism of rotational behavior at less than toxic doses. All agents tested blocked d-amphetamine-induced lethality and caused motor incoordination dose-responsively. SHPGE2, PGE2, C, and T caused statistically significant blockade of physostigmine-induced lethality. H and F were ineffective against physostigmine lethality. It was concluded that SHPGE2 and PGE2 demonstrated, qualitatively, a spectrum of neuroleptic like properties remarkably similar to C. |
| Databáze: | OpenAIRE |
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