Left ventricular global longitudinal strain in predicting CRT response: one more J-shaped curve in medicine
| Autor: | Wojciech Wróbel, Michał Orszulak, Witold Orszulak, Katarzyna Mizia-Stec, W. Kwasniewski, Artur Filipecki, Dagmara Urbańczyk-Swić, Adrianna Berger-Kucza |
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| Rok vydání: | 2021 |
| Předmět: |
Male
LVEF medicine.medical_specialty Percentile Time Factors Longitudinal strain Heart Ventricles Ventricular Function Left Cardiac Resynchronization Therapy Internal medicine medicine Humans Prospective Studies Left Ventricular Global Longitudinal Strain Aged Heart Failure Ejection fraction business.industry Stroke Volume Vascular surgery Prognosis medicine.disease Myocardial Contraction Peripheral Cardiac surgery Treatment Outcome Echocardiography Heart failure Etiology Cardiology CRT Original Article Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Heart and Vessels |
| ISSN: | 1615-2573 0910-8327 |
| DOI: | 10.1007/s00380-021-01770-w |
| Popis: | The aim of the study was: (1) to verify the hypothesis that left ventricular global longitudinal strain (LVGLS) may be of additive prognostic value in prediction CRT response and (2) to obtain such a LVGLS value that in the best optimal way enables to characterize potential CRT responders. Forty-nine HF patients (age 66.5 ± 10 years, LVEF 24.9 ± 6.4%, LBBB 71.4%, 57.1% ischemic aetiology of HF) underwent CRT implantation. Transthoracic echocardiography was performed prior to and 15 ± 7 months after CRT implantation. Speckle-tracking echocardiography was performed to assess longitudinal left ventricular function as LVGLS. The response to CRT was defined as a ≥ 15% reduction in the left ventricular end-systolic volume (∆LVESV). Thirty-six (73.5%) patients responded to CRT. There was no linear correlation between baseline LVGLS and ∆LVESV (r = 0.09;p = 0.56). The patients were divided according to the percentile of baseline LVGLS: above 80th percentile; between 80 and 40th percentile; below 40th percentile. Two peripheral groups (above 80th and below 40th percentile) formed “peripheral LVGLS” and the middle group was called “mid-range LVGLS”. The absolute LVGLS cutoff values were − 6.07% (40th percentile) and − 8.67% (80th percentile). For the group of 20 (40.8%) “mid-range LVGLS” patients mean ΔLVESV was 33.3 ± 16.9% while for “peripheral LVGLS” ΔLVESV was 16.2 ± 18.8% (p p = 0.015). Baseline LVGLS may have a potential prognostic value in prediction CRT response with relationship of inverted J-shaped pattern. “Mid-range LVGLS” values should help to select CRT responders, especially in non-ischemic HF etiology patients. |
| Databáze: | OpenAIRE |
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