Intraoperative High-Dose Dexamethasone in Cardiac Surgery and the Risk of Rethoracotomy
| Autor: | Dirk, van Osch, Jan M, Dieleman, Hendrik M, Nathoe, Marc P, Boasson, Jolanda, Kluin, Jeroen J H, Bunge, Arno P, Nierich, Peter M, Rosseel, Joost M, van der Maaten, Jan, Hofland, Jan C, Diephuis, Fellery, de Lange, Christa, Boer, Diederik, van Dijk, Jan G, Tijssen |
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| Přispěvatelé: | Anesthesiology, ICaR - Circulation and metabolism, Cardiothoracic Surgery, Intensive Care, Internal Medicine, Neurosciences, Radiology & Nuclear Medicine, Amsterdam Cardiovascular Sciences, Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
BLOOD-TRANSFUSION Blood transfusion medicine.medical_treatment Dexamethasone law.invention Postoperative Complications law Netherlands CARDIOPULMONARY BYPASS Incidence Middle Aged Cardiac surgery Treatment Outcome Thoracotomy Anesthesia Injections Intravenous Female TRIAL Tamponade Cardiology and Cardiovascular Medicine medicine.drug Pulmonary and Respiratory Medicine Adult Reoperation medicine.medical_specialty Adolescent Heart Diseases STEROID USE Placebo Young Adult medicine Cardiopulmonary bypass Humans Cardiac Surgical Procedures Adverse effect Glucocorticoids METAANALYSIS Aged Retrospective Studies Inflammation Intraoperative Care Dose-Response Relationship Drug business.industry INFLAMMATORY RESPONSE Perioperative Surgery UPDATE business Follow-Up Studies |
| Zdroj: | Annals of Thoracic Surgery, 100(6), 2237. Elsevier USA The Annals of Thoracic Surgery, 100(6), 2237-2243. Elsevier USA Annals of thoracic surgery, 100(6), 2237-2243. ELSEVIER SCIENCE INC Annals of Thoracic Surgery, 100(6), 2237-2243. Elsevier Inc. Annals of thoracic surgery, 100(6), 2237-2243. Elsevier USA van Osch, D, Dieleman, J M, Nathoe, H M, Boasson, M P, Kluin, J, Bunge, J J, Nierich, A P, Rosseel, P M, van der Maaten, J M, Hofland, J, Diephuis, J C, de Lange, F, Boer, C & van Dijk, D 2015, ' Intraoperative High-Dose Dexamethasone in Cardiac Surgery and the Risk of Rethoracotomy ', The Annals of Thoracic Surgery, vol. 100, no. 6, pp. 2237-2243 . https://doi.org/10.1016/j.athoracsur.2015.06.025 |
| ISSN: | 0003-4975 |
| Popis: | Background. Cardiac surgery with the use of cardiopulmonary bypass is associated with a systemic inflammatory response. Intraoperative corticosteroids are administered to attenuate this inflammatory response. The recent Dexamethasone for Cardiac Surgery (DECS) trial could not demonstrate a beneficial effect of dexamethasone on major adverse events in cardiac surgical patients. Previous studies suggest that corticosteroids may affect postoperative coagulation and blood loss, and therefore could influence the risk of surgical reinterventions. We investigated the effects of prophylactic intraoperative dexamethasone treatment on the rate of rethoracotomy after cardiac surgery.Methods. We performed a post-hoc additional data collection and analysis in the DECS trial. A total of 4,494 adult patients undergoing cardiac surgery with cardiopulmonary bypass were randomly assigned to intravenous dexamethasone (1.0 mg/kg) or placebo. The primary endpoint for the present study was the incidence of any rethoracotomy within the first 30 postoperative days. Secondary endpoints included the reason for rethoracotomy and the incidence of perioperative transfusion of blood products.Results. In the dexamethasone group, 217 patients (9.7%) underwent a rethoracotomy, and in the placebo group, 165 patients did (7.3%; relative risk 1.32, 95% confidence interval: 1.09 to 1.61, p = 0.005). The most common reason for rethoracotomy was tamponade in both groups: 3.9% versus 2.1%, respectively (relative risk 1.84, 95% confidence interval: 1.30 to 2.61, p Conclusions. Intraoperative high-dose dexamethasone administration in cardiac surgery was associated with an increased rethoracotomy risk. (C) 2015 by The Society of Thoracic Surgeons |
| Databáze: | OpenAIRE |
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