Effects of subchronic exposure to environmentally relevant concentrations of the herbicide atrazine in the Neotropical fish Astyanax altiparanae

Autor: Sérgio Luis Pinto da Matta, Amanda Alves Lozi, Kemilli P. Gregório, Jener Alexandre Sampaio Zuanon, Jerusa Maria de Oliveira, Stella Bicalho Silva, Reggiani Vilela Gonçalves, Mariella Bontempo Freitas, Ana Luiza Fonseca Destro, Ana Lúcia Salaro
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Gills
Male
Gill
Health
Toxicology and Mutagenesis
0211 other engineering and technologies
Histopathology
02 engineering and technology
010501 environmental sciences
medicine.disease_cause
Ecotoxicology
01 natural sciences
Environmental pollution
Lipid peroxidation
chemistry.chemical_compound
Animal science
Testis
medicine
Animals
GE1-350
Atrazine
Oxidative profile
Pesticides
0105 earth and related environmental sciences
021110 strategic
defence & security studies
Dose-Response Relationship
Drug
Characidae
Herbicides
Public Health
Environmental and Occupational Health
Yellow-tailed tetra
General Medicine
Pesticide
Pollution
Hormones
Environmental sciences
Oxidative Stress
medicine.anatomical_structure
Liver
chemistry
TD172-193.5
Hepatocyte
Neotropical fish
Female
Lipid Peroxidation
Water Pollutants
Chemical
Oxidative stress
Zdroj: Ecotoxicology and Environmental Safety, Vol 208, Iss, Pp 111601-(2021)
ISSN: 0147-6513
Popis: Atrazine (ATZ) is among the most widely used herbicides in the world, and yet it has a potential to contaminate aquatic environments due to pesticide leaching from agricultural areas. In the Neotropical region, studies about the effects of this herbicide in native aquatic wildlife is scarce.Our study aimed at investigating the effects of a 30-day exposure to a commercial atrazine formulation on oxidative stress parameters, histopathology in testis and liver, and hormone levels in males and female of yellow-tailed tetra fish (Astyanax altiparanae). Adults were exposed to low but environmentally relevant concentrations of atrazine as follows: 0 (CTL-control), 0.5 (ATZ0.5), 1 (ATZ1), 2 (ATZ2) and 10 (ATZ10) μg/L. Our results showed decreased GST activity in gills in all groups of exposed animals and increased CAT activity in gills from the ATZ10 group. In the liver, there was an increase in lipid peroxidation in fish from ATZ1 and ATZ2 groups. Histological analysis of the liver showed increased percentage of sinusoid capillaries in ATZ2 fish, increased vascular congestion in ATZ1 and increased leukocyte infiltration in the ATZ10 group. Hepatocyte diameter analysis revealed a decrease in cell size in all groups exposed to ATZ, and a decrease in hepatocyte nucleus diameter in ATZ1, ATZ2 and ATZ10 groups. Endocrine parameters did not show significant changes following ATZ exposure, although an increase of triiodothyronine/thyroxine (T3/T4) ratio was observed in ATZ2 fish. Our results provide evidence that even low, environmentally relevant concentrations of ATZ produced oxidative damage and histological alterations in adult yellow-tailed tetra.
Databáze: OpenAIRE
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