The renal arterial resistance index and renal allograft survival

Autor: Hermann Haller, Sebastian Ellis, Friedrich C. Luft, Michael Mengel, Anke Schwarz, Jörg Radermacher, Wilfried Gwinner, Markus Hiss, Ute Eisenberger, Stephan Stuht, Michael Burg
Přispěvatelé: MDC Library
Rok vydání: 2003
Předmět:
medicine.medical_specialty
Doppler Ultrasonography
Chronic Kidney Failure
Homologous Transplantation
medicine.medical_treatment
Biopsy
Urology
Renal function
570 Life Sciences
Kidney
Kidney Function Tests
Renal Circulation
610 Medical Sciences
Medicine
chemistry.chemical_compound
Renal Artery
Chronic allograft nephropathy
Predictive Value of Tests
medicine.artery
medicine
Humans
Transplantation
Homologous
Prospective Studies
Renal artery
Dialysis
Creatinine
business.industry
Graft Survival
Ultrasonography
Doppler
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Survival Analysis
Surgery
Transplantation
medicine.anatomical_structure
Treatment Outcome
chemistry
ROC Curve
Cardiovascular and Metabolic Diseases
Vascular resistance
Kidney Failure
Chronic
Vascular Resistance
business
Zdroj: New England Journal of Medicine 349 (2): 115-124.
ISSN: 1533-4406
0028-4793
Popis: BACKGROUND: Most renal transplants fail because of chronic allograft nephropathy or because the recipient dies, but no reliable factor predicting long-term outcome has been identified. We tested whether a renal arterial resistance index of less than 80 was predictive of long-term allograft survival. METHODS: The renal segmental arterial resistance index (the percentage reduction of the end-diastolic flow as compared with the systolic flow) was measured by Doppler ultrasonography in 601 patients at least three months after transplantation between August 1997 and November 1998. All patients were followed for three or more years. The combined end point was a decrease of 50 percent or more in the creatinine clearance rate, allograft failure (indicated by the need for dialysis), or death. RESULTS: A total of 122 patients (20 percent) had a resistance index of 80 or higher. Eighty-four of these patients (69 percent) had a decrease of 50 percent or more in creatinine clearance, as compared with 56 of the 479 patients with a resistance index of less than 80 (12 percent); 57 patients with a higher resistance index (47 percent) required dialysis, as compared with 43 patients with a lower resistance index (9 percent); and 36 patients with a higher resistance index (30 percent) died, as compared with 33 patients with a lower resistance index (7 percent) (P
Databáze: OpenAIRE
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