Treatment of actinide exposures: a review of Ca-DTPA injections inside CEA-COGEMA plants
| Autor: | L. Carbone, Louise Grappin, Jean Piechowski, Philippe Berard, Catherine Courtay, Xavier Castagnet, M.O. Neron, F. Ménétrier, Jean-Pierre Le Goff |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Actinoid Series Elements Dose Radiation-Protective Agents Occupational physicians Radiation Dosage Models Biological Whole-Body Counting Occupational medicine Occupational Exposure medicine Humans Computer Simulation Radiology Nuclear Medicine and imaging Radiation Injuries Adverse effect Chelating Agents Radiation Dose-Response Relationship Drug Radiological and Ultrasound Technology Medical treatment business.industry Public Health Environmental and Occupational Health Authorization Collective work Environmental Exposure General Medicine Pentetic Acid Surgery Treatment Outcome Emergency medicine Body Burden business Target organ Power Plants |
| Zdroj: | Radiation Protection Dosimetry. 127:435-439 |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/ncm296 |
| Popis: | Calcium diethylenetriamine pentacetate (Ca-DTPA) has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This paper is a survey of the injections Ca-DTPA administered as a chelating molecule and it will be a part of the authorisation process for Ca-DTPA by intravenous administration. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contamination were reported. These employees were followed by occupational physicians according to the current French regulations. These incidents took place at work, were most often minor, not requiring follow-up treatment. The authors present (1) a synthesis of the most recent findings. Due to its short biological half-time and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary (2) data concerning these 1158 injections (route of contamination, dosage, adverse effects, etc.) The authors also investigated a study on the efficacy of the product on a group of persons having received five or more injections. These results were compared with the efficacy estimated theoretically. Dosages and therapeutic schemes were proposed based on these observations. This synthesis is the result of a collective work having mobilised the occupational medicine departments, the medical laboratories inside a working group CEA-COGEMA-SPRA. |
| Databáze: | OpenAIRE |
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