Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators
| Autor: | S. C. Puri, Amit Gupta, Mushtaq A. Qurishi, Gulam Nabi Qazi, A. Khajuria, Kanaya Lal Dhar, Bilal A. Bhat |
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| Rok vydání: | 2005 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry T-Lymphocytes medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Pharmacognosy Biochemistry Steroid Lactones Mice chemistry.chemical_compound Drug Discovery medicine Animals Immunologic Factors Hypersensitivity Delayed Molecular Biology chemistry.chemical_classification Mice Inbred BALB C biology Traditional medicine Tumor Necrosis Factor-alpha Organic Chemistry Biological activity biology.organism_classification Withanolide chemistry Datura Phytochemical Interleukin-2 Molecular Medicine Spleen Lactone Solanaceae |
| Zdroj: | Bioorganic & Medicinal Chemistry. 13:6672-6677 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2005.07.040 |
| Popis: | Phytochemical investigation of Datura quercifolia (Solanaceae) plant yielded a new datura lactone, 1beta,5alpha,12alpha-trihydroxy-6alpha,7alpha,24alpha,25alpha-diepoxy-20S,22R with-2-enolide (1), along with two known compounds, 2 and 3. The structure of 1 was established on the basis of spectral analysis, as well as by its chemical transformation into known datura lactones. These compounds have been evaluated for immunomodulatory activity by observing their effect on antibody production, T-cell and B-cell activation, and cytokine production from splenocytes. Compound 2 was found to be the most promising immunostimulator in the present study. |
| Databáze: | OpenAIRE |
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