Expression of transglutaminase 1 in human hair follicles, sebaceous glands and sweat glands
| Autor: | Hiroshi Shimizu, Kozo Yoneda, Masanori Akiyama, Sadao Imamura, S.-Y. Kim, Kazumasa Morita |
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| Rok vydání: | 1998 |
| Předmět: |
Sebaceous gland
Pathology medicine.medical_specialty Immunoelectron microscopy Gene Expression Dermatology In situ hybridization Biology Outer root sheath Polymerase Chain Reaction Inner root sheath Sebaceous Glands Sweat gland medicine Humans RNA Messenger Fluorescent Antibody Technique Indirect Microscopy Immunoelectron In Situ Hybridization Cuticle (hair) Scalp Transglutaminases integumentary system Hair follicle Molecular biology Sweat Glands medicine.anatomical_structure Microscopy Fluorescence Hair Follicle |
| Zdroj: | British Journal of Dermatology. 138:37-44 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1046/j.1365-2133.1998.02024.x |
| Popis: | To explore the function of the enzyme transglutaminase 1 (TGase 1), its distribution was analysed by immunofluorescence microscopy, postembedding immunoelectron microscopy and in situ hybridization. TGase 1 was expressed in the outer root sheath (ORS) cells in the distal portion of the isthmus and infundibulum of human hair follicles. In the level of the proximal and middle portion of the isthmus, TGase 1 was observed in the keratinized area of the inner root sheath (IRS) and ORS cells. In the bulbar and suprabulbar portions, TGase 1 was present in the ORS and IRS cells. The cortex and medulla cells in these regions also contained TGase 1. A high level of fluorescence was observed at the cuticle of the cortex. Sebaceous and sweat gland cells contained abundant TGase 1. Possible functions of TGase 1 in these epidermal appendages are discussed. |
| Databáze: | OpenAIRE |
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