Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL
| Autor: | Roland Vetter, Jonna Hänsch, Daniela Grimm, Judith Weiss, Peter Kossmehl, Maria Schlesener, Norbert Wendt, Reinhold Kreutz, Angela Schulz |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Aging Multifactorial Inheritance Quantitative Trait Loci 030204 cardiovascular system & hematology Kidney Diabetic nephropathy Excretion 03 medical and health sciences 0302 clinical medicine Quantitative Trait Heritable Animals Congenic Diabetes mellitus Internal medicine Rats Inbred SHR medicine Albuminuria Animals 030304 developmental biology 0303 health sciences Sex Characteristics Proteinuria business.industry Glomerulosclerosis Rats Inbred Strains General Medicine medicine.disease Chromosomes Mammalian Rats Endocrinology medicine.anatomical_structure Female Kidney Diseases medicine.symptom business Kidney disease |
| Zdroj: | Schulz, A, Schlesener, M, Weiss, J, Hänsch, J, Wendt, N, Kossmehl, P, Grimm, D, Vetter, R & Kreutz, R 2008, ' Protective effect of female gender on the development of albuminuria in a polygenetic rat model is enhanced further by replacement of a major autosomal QTL ', Clinical Science, vol. 114, no. 4, pp. 305-11 . https://doi.org/10.1042/CS20070300 |
| Popis: | Clinical and experimental studies indicate that the progression of renal disease is faster in males than females. These observations are corroborated by a sexual dimorphism observed in the polygenetic MWF (Munich Wistar Frömter) rat model. The age-dependent spontaneous progression of increased UAE (urinary albumin excretion) in male MWF rats is influenced by multiple QTLs (quantitative trait loci). In contrast, female MWF rats only develop a slight increase in UAE, while the role of genetic factors for this phenotype is unknown. In the present study, we show that, compared with resistant SHRs (spontaneously hypertensive rats), both male and female MWF rats develop a significant increase in UAE at 24 weeks of age (P |
| Databáze: | OpenAIRE |
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