Impact of human milk pasteurization on gastric digestion in preterm infants: a randomized controlled trial

Autor: Patrick Pladys, Emelyne Dirson, Yann Le Gouar, Amélie Deglaire, Florian Kroell, Olivia Ménard, Claire Bourlieu, Amandine Bellanger, Samira de Oliveira, Didier Dupont
Přispěvatelé: Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Department of Pediatrics, University Hospital, Faculty of Medicine, Université de Rennes (UR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Medicine (miscellaneous)
Pasteurization
pasteurisation
digestion
human health
law.invention
law
[SDV.IDA]Life Sciences [q-bio]/Food engineering
Ingestion
Food science
Infant Nutritional Physiological Phenomena
2. Zero hunger
Lactalbumin
Nutrition and Dietetics
biology
Chemistry
Lactoferrin
enfant prématuré
Stomach
Fatty Acids
Caseins
human milk
santé humaine
Hydrogen-Ion Concentration
Milk Proteins
premature infant
3. Good health
aliment pasteurise
medicine.anatomical_structure
nutrition infantile
Holder pasteurization
Dietary Proteins
Digestion
Infant
Premature
Lipolysis
preterm infant
03 medical and health sciences
medicine
Dietary Carbohydrates
Humans
Serum Albumin
lait humain
pasteurizing
030109 nutrition & dietetics
Gastric emptying
Milk
Human
infant nutrition
Infant
Sterol Esterase
Dietary Fats
Gastric Emptying
Gastric Mucosa
Proteolysis
biology.protein
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: The American Journal of Clinical Nutrition
The American Journal of Clinical Nutrition, 2017, 105 (2), ⟨10.3945/ajcn.116.142539⟩
American Journal of Clinical Nutrition
American Journal of Clinical Nutrition, American Society for Nutrition, 2017, ⟨10.3945/ajcn.116.142539⟩
American Journal of Clinical Nutrition, American Society for Nutrition, 2017, 105 (2), ⟨10.3945/ajcn.116.142539⟩
ISSN: 0002-9165
1938-3207
DOI: 10.3945/ajcn.116.142539⟩
Popis: Background: Holder pasteurization has been reported to modify human milk composition and structure by inactivating bile salt–stimulated lipase (BSSL) and partially denaturing some of its proteins, potentially affecting its subsequent digestion. Objective: We sought to determine the impact of human milk pasteurizationon gastric digestion (particularly for proteins and lipids) in preterm infants who were fed their mothers’ own milk either raw or pasteurized. Design: In a randomized controlled trial, 12 hospitalized tube-fed preterm infants were their own control group in comparing the gastric digestion of raw human milk (RHM) with pasteurized human milk (PHM). Over a 6-d sequence, gastric aspirates were collected 2 times/d before and after RHM or PHM ingestion. The impact of milk pasteurization digestive kinetics and disintegration was tested with the use of a general linear mixed model. Results: Despite inactivating BSSL, instantaneous lipolysis was not affected by pasteurization (mean 6 SD at 90 min: 12.6% 6 4.7%; P . 0.05). Lipolysis occurred in milk before digestion and was higher for PHM than for RHM (mean 6 SD: 3.2% 6 0.6% and 2.2% 6 0.8%, respectively; P , 0.001). Pasteurization enhanced the proteolysis of lactoferrin (P , 0.01) and reduced that of a-lactalbumin (only at 90 min) (P , 0.05). Strong emulsion destabilization was observed, with smaller aggregates and a higher specific surface for PHM (P , 0.05). Pasteurization did not affect gastric emptying (w30-min half time) or pH (mean 6 SD: 4.4 6 0.8) at 90 min. Conclusions: Overall, pasteurization had no impact on the gastric digestion of lipids and some proteins from human milk but did affect lactoferrin and a-lactalbumin proteolysis and emulsion disintegration. Freeze-thawing and pasteurization increased the milk lipolysis before digestion but did not affect gastric lipolysis. Possible consequences on intestinal digestion and associated nutritional outcomes were not considered in this study. This trial was registered at clinicaltrials.gov as NCT02112331.
Databáze: OpenAIRE
Externí odkaz: