Metalloriboswitches: RNA-based inorganic ion sensors that regulate genes
| Autor: | Joseph E. Wedekind, Debapratim Dutta, Ivan A. Belashov, Jermaine L. Jenkins |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Riboswitch Bacteria 030106 microbiology RNA Minireviews Cell Biology Biology Biochemistry Divalent Cell biology 03 medical and health sciences RNA Bacterial Ion homeostasis chemistry Metals Heavy Transcriptional regulation Nucleic Acid Conformation Molecular Biology Gene Intracellular Ion channel |
| Zdroj: | The Journal of biological chemistry. 292(23) |
| ISSN: | 1083-351X |
| Popis: | Divalent ions fulfill essential cellular roles and are required for virulence by certain bacteria. Free intracellular Mg2+ can approach 5 mm, but at this level Mn2+, Ni2+, or Co2+ can be growth-inhibitory, and magnesium fluoride is toxic. To maintain ion homeostasis, many bacteria have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux channels. Here, we review current insights into these "metalloriboswitches," emphasizing ion-specific binding by structured RNA aptamers and associated conformational changes in downstream signal sequences. This riboswitch-effector interplay produces a layer of gene regulatory feedback that has elicited interest as an antibacterial target. |
| Databáze: | OpenAIRE |
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