Expression of Laminin Receptor 1 in Normal, Hyperplastic, and Malignant Endometrium
| Autor: | Gülay Bulut, Suleyman Ozen, Yasar Unlu, Zehra Kucukaydin, Mertihan Kurdoglu, Zehra Kurdoglu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Ribosomal Proteins 0301 basic medicine Pathology medicine.medical_specialty Endometrium Pathology and Forensic Medicine Receptors Laminin 03 medical and health sciences 0302 clinical medicine medicine Atypia Humans Aged Basement membrane biology business.industry Endometrial cancer Obstetrics and Gynecology Cancer Middle Aged Hyperplasia medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Endometrial Neoplasms Endometrial hyperplasia Phenotype 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Endometrial Hyperplasia Disease Progression biology.protein Female Antibody business Precancerous Conditions |
| Zdroj: | International Journal of Gynecological Pathology. 38:326-334 |
| ISSN: | 0277-1691 |
| Popis: | Laminin receptor 1 may have a role in the progression from endometrial hyperplasia with or without atypia to endometrial cancer. Therefore, we aimed to investigate the pattern, percentage, and intensity of laminin receptor 1 expression in normal, hyperplastic, and neoplastic endometrium. Paraffin blocks of 131 specimens with the diagnoses of normal endometrium (n=25), endometrial hyperplasia with atypia (n=21) or without atypia (n=55), and endometrial cancer (n=30) were immunostained with laminin receptor 1 antibody, and its expression percentage, pattern, and intensity in the epithelial cytoplasm, basement membrane, and endometrial stroma of these tissues were assessed. When compared with hyperplasia with or without atypia and endometrial cancer, the percentage of nonstaining with laminin receptor 1 in the epithelial basement membrane was higher (96%), and the percentage of 0.05). Disease progression-related gradual increment in laminin receptor 1 expression in the epithelial basement membranes of hyperplastic endometrium with or without atypia and cancer of endometrium reveals that it may play a substantial role in the transition from premalignant to the malignant state of endometrial lesions. |
| Databáze: | OpenAIRE |
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