'Eat me' imaging and therapy
| Autor: | Andrei Maiseyeu, Vaishali Bagalkot, Jeffrey A. Deiuliis, Sanjay Rajagopalan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Diagnostic Imaging
0301 basic medicine Pharmaceutical Science Inflammation Phosphatidylserines CCL2 Biology Article 03 medical and health sciences Immune system Drug Therapy medicine Animals Humans Drug Carriers Innate immune system Immunity Innate Interleukin 10 030104 developmental biology Pharmaceutical Preparations Immunology Drug delivery Interleukin 12 Tumor necrosis factor alpha medicine.symptom Neuroscience |
| Zdroj: | Advanced Drug Delivery Reviews. 99:2-11 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2016.01.009 |
| Popis: | Clearance of apoptotic debris is a vital role of the innate immune system. Drawing upon principles of apoptotic clearance, convenient delivery vehicles including intrinsic anti-inflammatory characteristics and specificity to immune cells can be engineered to aid in drug delivery. In this article, we examine the use of phosphatidylserine (PtdSer), the well-known "eat-me" signal, in nanoparticle-based therapeutics making them highly desirable "meals" for phagocytic immune cells. Use of PtdSer facilitates engulfment of nanoparticles allowing for imaging and therapy in various pathologies and may result in immunomodulation. Furthermore, we discuss the targeting of the macrophages and other cells at sites of inflammation in disease. A thorough understanding of the immunobiology of "eat-me" signals is requisite for the successful application of "eat-me"-bearing materials in biomedical applications. |
| Databáze: | OpenAIRE |
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