Silibinin attenuates methotrexate-induced pulmonary injury by targeting oxidative stress
| Autor: | Serkan Yaşar Çelik, Nigar Yilmaz, Serdar Kalemci, Nigar Dirican, Yaşar Topal, Mehmet Ilkay Kosar, Halil Beydilli, Irfan Altuntas |
|---|---|
| Přispěvatelé: | MÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Cancer Research Antioxidant Pulmonary Toxicity Pulmonary toxicity medicine.medical_treatment Silibinin Pharmacology medicine.disease_cause Nitric oxide Superoxide dismutase chemistry.chemical_compound Immunology and Microbiology (miscellaneous) Medicine skin and connective tissue diseases chemistry.chemical_classification biology business.industry Glutathione peroxidase General Medicine Articles Methotrexate chemistry Myeloperoxidase Immunology biology.protein Rat business Oxidative stress |
| Popis: | WOS: 000358679400018 PubMed ID: 26622344 The aim of the present study was to assess the protective effect of silibinin against methotrexate (MTX)-induced pulmonary toxicity. Rats were divided into four groups (MTX, MTX + silibinin, silibinin and control. MTX was injected intraperitoneally (i.p) into female Wistar rats (10 mg/kg/day for 3 days), which resulted in significant increases in the serum levels of alanine aminotransferase, aspartate aminotransferase and oxidant enzymes, including nitric oxide and myeloperoxidase. Furthermore, significant reductions were detected in the serum activity levels of the antioxidative enzymes, glutathione peroxidase and superoxide dismutase, when compared with the control group. However, administration of silibinin (100 mg/kg/day for 10 days, i.p.) was shown to ameliorate the MTX-induced pulmonary toxicity, as indicated by the normalization of the oxidative stress parameters. Furthermore, silibinin treatment was demonstrated to reduce the histopathological changes associated with MTX. In conclusion, silibinin exhibited protective effects against MTX-induced pulmonary toxicity, which may be attributed to its antioxidant activity. |
| Databáze: | OpenAIRE |
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