Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity
| Autor: | James E. Hutchison, Vihangi Hindagolla, Hagai Abeliovich, Matthew G. Boenzli, Jun Ding, Alan T. Bakalinsky, John M. Miller, Mark R. Smith, Jeffrey A. Greenwood |
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| Rok vydání: | 2013 |
| Předmět: |
Microbial Viability
Ecology Mutant Saccharomyces cerevisiae Nanoparticle Genetics and Molecular Biology Mitochondrion Biology biology.organism_classification Applied Microbiology and Biotechnology Yeast Biochemistry Drug Resistance Fungal Colloidal gold Toxicity Nanoparticles Gold Gene Gene Deletion Metabolic Networks and Pathways Food Science Biotechnology |
| Zdroj: | Applied and Environmental Microbiology. 79:728-733 |
| ISSN: | 1098-5336 0099-2240 |
| DOI: | 10.1128/aem.01737-12 |
| Popis: | Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion. |
| Databáze: | OpenAIRE |
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