Stool therapy may become a preferred treatment of recurrentClostridium difficile?
| Autor: | Arpita Vyas, Heidi E L’Esperance, Dinesh Vyas |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Field Of Vision Colonoscopy Disease law.invention Feces fluids and secretions Randomized controlled trial Recurrence law Internal medicine medicine Humans Intensive care medicine Intubation Gastrointestinal Enterocolitis Pseudomembranous Enterocolitis medicine.diagnostic_test Disease Eradication Clostridioides difficile business.industry Gastroenterology General Medicine Clostridium difficile Anti-Bacterial Agents Treatment Outcome Vancomycin medicine.symptom business medicine.drug |
| Zdroj: | World Journal of Gastroenterology. 19:4635 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v19.i29.4635 |
| Popis: | Fecal enemas were first reported to successfully treat life threatening enterocolitis in 1958, but fecal therapy to treat Clostridium difficile (C. difficile) infection has remained esoteric and not well investigated until recently. In the past few years, systematic reviews of case series and case reports of fecal microbiota transplant for recurrent C. difficile infection have become available and validate use of fecal transplant for C. difficile enterocolitis. Methods of fecal transplant reported in the literature include: nasogastric tube, gastroscope, duodenal tube, colonoscopy, rectal tube, and fecal enemas administered at home; no method has been shown to be superior. A recent randomized study published in New England Journal of Medicine found fecal transplant to be superior to oral vancomycin alone in treatment of recurrent C. difficile enterocolitis. The significance of this trial cannot be underestimated as it lends credibility to the idea of intentionally using microbes to combat disease, providing an alternative to the older paradigm of disease eradication through use of antimicrobials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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