Helicobacter pyloriincidence and re-infection in the AklavikH. pyloriProject

Autor: Sally Carraher, Hsiu-Ju Chang, Rachel Munday, Karen J. Goodman, the CANHelp Working Group
Rok vydání: 2013
Předmět:
Male
Helicobacter pylori infection
Health (social science)
Epidemiology
Aboriginal health
Northwest Territories
Arctic
0302 clinical medicine
collaborative research
Cumulative incidence
030212 general & internal medicine
Young adult
Child
Aged
80 and over
medicine.diagnostic_test
biology
Arctic Regions
Incidence
Incidence (epidemiology)
Age Factors
epidemiology
incidence
General Medicine
Middle Aged
Anti-Bacterial Agents
3. Good health
Breath Tests
Inuit
Child
Preschool
Drug Therapy
Combination
Female
030211 gastroenterology & hepatology
Adult
Community-Based Participatory Research
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
Adolescent
lcsh:RC955-962
Urea breath test
Infectious Disease
Drug Administration Schedule
Helicobacter Infections
Young Adult
03 medical and health sciences
Sex Factors
Internal medicine
Supplement 1
2013
medicine
Humans
Aged
Helicobacter pylori
business.industry
Infant
Newborn
Public Health
Environmental and Occupational Health
Infant
Anti-Ulcer Agents
biology.organism_classification
Surgery
business
Zdroj: International Journal of Circumpolar Health
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013)
International Journal of Circumpolar Health; Vol 72 (2013)
ISSN: 2242-3982
2008-2010
1797-237X
1239-9736
DOI: 10.3402/ijch.v72i0.21594
Popis: Background. The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who underwent a urea breath test (UBT) between 2007 and 2010 were H. pylori-positive. From 2008 to 2010, we offered treatment to H. pylori-positive participants and 113 consented to this treatment. Objective. We estimated H. pylori incidence in AHPP participants who initially tested negative and the re-infection frequency in initially positive participants who were successfully treated to clear the infection. Methods. Participants who were initially H. pylori-negative or negative after treatment during 2008-2010 were eligible for inclusion. From November 2011 to June 2012, participants were offered a UBT and the samples were analyzed using infrared spectroscopy (IRIS). Participants with a positive test result were classified as new cases for estimating incidence among participants testing negative at baseline and re-infection among those successfully treated for H. pylori infection. Results. Among 38 initially negative participants, follow-up UBT showed that 33 remained negative, 3 were positive, and 2 had uncertain status. The estimated incidence proportion during the follow-up period was 8.3% (95% CI: 1.8-22.0%). Among 43 participants with a negative post-treatment UBT, 41 remained negative and 2 were positive. The estimated re-infection proportion during the follow-up period was 4.7% (95% CI: 0.6-16.0%). The frequency of new cases was similar in males and females. Aboriginal participants had a combined re-infection/incidence rate of 2.4% per year (95% CI: 0.8-5.9% per year). All 9 non-Aboriginal participants remained free from infection throughout the study period, as did all 23 participants aged 55 years and above. Conclusions. The AHPP has substantially reduced the burden of infection in Aklavik since 2008. Continued monitoring, treatment, community engagement and knowledge translation activities are needed to ensure a lasting benefit of the project. Keywords: Helicobacter pylori infection; Aboriginal health; collaborative research; epidemiology; incidence; Arctic (Published: 5 August 2013) This paper is part of Supplement 1, 2013, ICCH15 Proceedings . More papers from this Supplement can be found here . Citation: Int J Circumpolar Health 2013, 72 : 21594 - http://dx.doi.org/10.3402/ijch.v72i0.21594
Databáze: OpenAIRE
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