The brain parenchyma has a type I interferon response that can limit virus spread
| Autor: | Didem Göz Aytürk, Elaine O’Loughlin, Oleg Butovsky, Ryan Chrenek, Eugene Drokhlyansky, Constance L. Cepko, Timothy K. Soh, Charlotte Madore |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male viruses Virus Replication Virus 03 medical and health sciences Mice Immune system Immune privilege Interferon Parenchyma medicine Animals Parenchymal Tissue Multidisciplinary Innate immune system biology Microglia Brain Vesiculovirus biology.organism_classification Virology Immunity Innate Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure PNAS Plus Vesicular stomatitis virus Immunology Interferon Type I Vesicular Stomatitis medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 114(1) |
| ISSN: | 1091-6490 |
| Popis: | The brain has a tightly regulated environment that protects neurons and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an immune response. We tested the ability of the brain to initiate an innate immune response to a virus, which was directly injected into the brain parenchyma, and to determine whether this response could limit viral spread. We injected vesicular stomatitis virus (VSV), a transsynaptic tracer, or naturally occurring VSV-derived defective interfering particles (DIPs), into the caudate-putamen (CP) and scored for an innate immune response and inhibition of virus spread. We found that the brain parenchyma has a functional type I interferon (IFN) response that can limit VSV spread at both the inoculation site and among synaptically connected neurons. Furthermore, we characterized the response of microglia to VSV infection and found that infected microglia produced type I IFN and uninfected microglia induced an innate immune response following virus injection. |
| Databáze: | OpenAIRE |
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