Aging Changes Effective Connectivity of Motor Networks During Motor Execution and Motor Imagery
Autor: | Li Wang, Chen Liu, Ye Zhang, Linqiong Sang, Pengyue Li, Rubing Yan, Mingguo Qiu, Jingna Zhang |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Aging effective connectivity Cognitive Neuroscience lcsh:RC321-571 03 medical and health sciences motor network motor imagery 0302 clinical medicine Neurochemical Motor imagery medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research medicine.diagnostic_test Granger causality analysis Supplementary motor area Neurodegeneration Correction medicine.disease SMA motor execution 030104 developmental biology medicine.anatomical_structure Functional magnetic resonance imaging Psychology Neuroscience 030217 neurology & neurosurgery Motor execution |
Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 11 (2019) |
ISSN: | 1663-4365 |
Popis: | Age-related neurodegenerative and neurochemical changes are considered to be the basis for the decline of motor function; however, the change of effective connections in cortical motor networks that come with aging remains unclear. Here, we investigated the age-related changes of the dynamic interaction between cortical motor regions. Twenty young subjects and 20 older subjects underwent both right hand motor execution (ME) and right hand motor imagery (MI) tasks by using functional magnetic resonance imaging. Conditional Granger causality analysis (CGCA) was used to compare young and older adults’ effective connectivity among regions of the motor network during the tasks. The more effective connections among motor regions in older adults were found during ME; however, effective within-domain hemisphere connections were reduced, and the blood oxygenation level dependent (BOLD) signal was significantly delayed in older adults during MI. Supplementary motor area (SMA) had a significantly higher In+Out degree within the network during ME and MI in older adults. Our results revealed a dynamic interaction within the motor network altered with aging during ME and MI, which suggested that the interaction with cortical motor neurons caused by the mental task was more difficult with aging. The age-related effects on the motor cortical network provide a new insight into our understanding of neurodegeneration in older individuals. |
Databáze: | OpenAIRE |
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