Hepatitis C virus epidemiology in Central-West Tunisia: a population-based cross-sectional study
| Autor: | Walid Hammemi, Malek Badreddine, Henda Triki, Adel Gharbi, Ghassen Kharroubi, Amel Sadraoui, Anissa Chouikha, Marwa Khedhiri, Jihene Bettaieb, Afif Ben Salah, Zina Meddeb, Nabil Belhadj Hmida, Ahlem Ben Yahia |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Tunisia Adolescent Genotype Hepatitis C virus Prevalence Hepacivirus Biology Viral Nonstructural Proteins medicine.disease_cause 03 medical and health sciences Young Adult Seroepidemiologic Studies Virology Internal medicine medicine Seroprevalence Humans Child Genotyping Phylogeny 030304 developmental biology Aged Hepatitis 0303 health sciences 030306 microbiology Incidence (epidemiology) General Medicine Hepatitis C Hepatitis C Antibodies Middle Aged medicine.disease Cross-Sectional Studies Child Preschool Female Viral load |
| Zdroj: | Archives of virology. 164(9) |
| ISSN: | 1432-8798 |
| Popis: | This study aimed to assess the seroprevalence, viraemia and genotype distribution of hepatitis C virus (HCV) in a region in Central-West Tunisia. A door-to-door cross-sectional study was conducted on a randomly selected sample. A total of 3178 individuals aged 5 to 74 years and members of 935 families were investigated. Seroprevalence of HCV was assessed using ELISA tests. The viral load was determined by real-time RT-PCR, and HCV genotyping was conducted by amplification and sequencing in the NS5b genomic region. The global prevalence of HCV antibodies was 3.32% (95% confidence interval [CI]: 2.72-4.00). It was significantly higher in women: 4.47% vs. 2.16% in men, p = 0.001. Seroprevalence increased with age, and the highest rates were found in the 50- to 59-year-old age group (12.90%, 95% CI: 9.45-16.86), suggesting a cohort effect with very low contribution of intrafamilial transmission. Genotyping showed a predominance of subtype 1b (84.6%), with cocirculation of subtypes 2c (9.6%), 1a (1.9%), 1d (1.9%) and 2k (1.9%), similar to the previously reported genotype distribution in Tunisia and with no genetic clusters specific to the study region. These results indicate a higher endemicity of HCV infection when compared to the previously reported nationwide surveillance data. This study provides valuable data that can contribute to current strategies to eliminate hepatitis C. |
| Databáze: | OpenAIRE |
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