Inhibition of Diffusion Chamber (DC) Granulopoiesis by Anti-CSF Serum
| Autor: | Emilie Gerard, Gundabhaktha Chikkappa, Eugene P. Cronkite, Arland L. Carsten, Richard K. Shadduck |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Antiserum
Diffusion chamber Pathology medicine.medical_specialty Cell Survival In Vitro Techniques Biology Molecular biology Granulopoiesis Antibodies General Biochemistry Genetics and Molecular Biology In vitro Hematopoiesis Colony-Forming Units Assay Mice Colony-Stimulating Factors Leukopoiesis Antibody Specificity Immune serums Cell culture medicine Animals Female Stem cell Granulocytes |
| Zdroj: | Experimental Biology and Medicine. 158:542-549 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-158-40242 |
| Popis: | Diffusion chamber granulopoiesis was studied in irradiated mice injected with anti-colony stimulating factor (CSF)serum. Total cellularity, proliferative and nonproliferative granulocytes were markedly suppressed by 4 days injection of antiserum. Moreover, granulocytic stem cells were markedly decreased. This suggests that CSF is necessary for maintaining the integrity of the granulocytic stem cell and for inducing differentiating granulopoiesis. |
| Databáze: | OpenAIRE |
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