Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected cases
| Autor: | Rolf Teschke, Karl-Heinz Hennermann, Alexander Schwarzenboeck |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Toxic hepatitis Drug medicine.medical_specialty media_common.quotation_subject Pharmacology Severity of Illness Index Drug Administration Schedule Young Adult Risk Factors Internal medicine medicine Humans Aged Kava media_common Aged 80 and over Hepatitis Hepatology Plant Extracts business.industry Gastroenterology Middle Aged Prognosis medicine.disease Causality Increased risk Anti-Anxiety Agents Patient Compliance Female Chemical and Drug Induced Liver Injury medicine.symptom business Prolonged treatment Adverse drug reaction Phytotherapy |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 20:1182-1193 |
| ISSN: | 0954-691X |
| DOI: | 10.1097/meg.0b013e3283036768 |
| Popis: | BACKGROUND/AIMS Hepatotoxicity has been previously suspected by national regulatory agencies in 26 patients in causal relationship with the treatment by kava extracts commonly used as herbal anxiolytic drugs. METHODS A quantitative causality assessment was undertaken using the system of the Council for International Organizations of Medical Sciences, scale of objective probability scoring. RESULTS Causality was unassessable, unrelated, or excluded in 16 patients owing to lack of temporal association and causes independent of kava or comedicated drugs. Low Council for International Organizations of Medical Sciences scores additionally resulted in excluded or unlikely causality assessments (n=2), leaving a total of eight patients with various degrees of causality for kava +/- comedicated drugs. Only one out of these eight patients adhered to the regulatory recommendations regarding both daily dose ( |
| Databáze: | OpenAIRE |
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