Author Correction: TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice
| Autor: | Lei Chen, Chunfeng Wu, Ling Chen, Yingchun Li, Dong An, Li Zhou, Weixing Xu, Yichao Zhu, Zhouqing Wang, Yimei Du, Sha Sha, Aidong Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
TRPV4 Male Cancer Research Inflammasomes Inflammatory response Morpholines Immunology Cell death in the nervous system TRPV Cation Channels Temporal lobe Inflammasome 03 medical and health sciences Cellular and Molecular Neuroscience Epilepsy Mice 0302 clinical medicine Text mining Status Epilepticus Leucine Medicine Animals Pyrroles Inflammation Neurons Mice Inbred ICR Sulfonamides business.industry Published Erratum Pilocarpine Correction Cell Biology medicine.disease 030104 developmental biology Epilepsy Temporal Lobe 030220 oncology & carcinogenesis Astrocytes Microglia business Neuroscience medicine.drug |
| Zdroj: | Cell Death & Disease |
| ISSN: | 2041-4889 |
| Popis: | Activation of transient receptor potential vanilloid 4 (TRPV4) induces neuronal injury. TRPV4 activation enhances inflammatory response and promotes the proinflammatory cytokine release in various types of tissue and cells. Hyperneuroinflammation contributes to neuronal damage in epilepsy. Herein, we examined the contribution of neuroinflammation to TRPV4-induced neurotoxicity and its involvement in the inflammation and neuronal damage in pilocarpine model of temporal lobe epilepsy in mice. Icv. injection of TRPV4 agonist GSK1016790A (GSK1016790A-injected mice) increased ionized calcium binding adapter molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP) protein levels and Iba-1-positive (Iba-1 |
| Databáze: | OpenAIRE |
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